MARC details
| 000 -LEADER |
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04118ntm a2200337 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251223182547.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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t||||fr|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251223t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010176 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKKP .J83 2025 r Thesis |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Juanni Zhang, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Fabrication of biocompatible chitin-derived dual-network nanocomposite hydrogels with antibacterial and blood coagulation properties / |
| Statement of responsibility, etc. |
Juanni Zhang |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Kuantan Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xvii, 252 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Chemical and Process Engineering Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Chitin, the second most abundant natural polysaccharide after cellulose, is a renewable biopolymer composed of β-(1→4)-linked N-acetylglucosamine units. Despite its excellent biocompatibility, degradability, and modifiability, the practical application of chitin remains limited by its poor solubility. Chemical modification can significantly enhance chitin's solubility and functionality, facilitating the research and development of chitin-derived hydrogels. However, chitin-derived hydrogels still encounter challenges such as insufficient mechanical strength, poor biocompatibility, and limited antibacterial properties. To address the limitations, this study integrates dual-network and nanocomposite technologies to develop chitosan/HAp@Zn dual-network nanocomposite hydrogels and quaternized chitosan/chitin nanowhisker dual-network nanocomposite hydrogels, aiming to enhance their properties and broaden their potential applications. The former comprises chitosan, zinc-loaded nano-hydroxyapatite (HAp@Zn), acrylylglycine (ACG), and N-benzylacrylamide (NBAA), while the latter consists of quaternized chitosan (QCS), chitin nanowhiskers (ChWs), acrylic acid, acrylamide, and Zn²+. The influence of the concentration of each component on the properties of the hydrogel was investigated by one-factor-at-a-time analysis, and the structure of the hydrogel was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Additionally, the physical properties (mechanical strength, swelling property, rheological behavior) and biological properties (antibacterial, cytotoxicity, hemolysis, blood coagulation) were systematically examined. The results indicate that the chitosan/HAp@Zn hydrogel possesses excellent mechanical strength and pH-responsive swelling performance. Its maximum mechanical strength is 495.2 kPa and its equilibrium swelling rate is 23.4g/g. The maximum antibacterial rates of E. coli and S. aureus reached 100% and 99.9% respectively. These hydrogels are not cytotoxic and can demonstrate excellent blood compatibility by adjusting their composition. Additionally, they were found to have a good ability for blood coagulation. For the QCS/ChWs hydrogels, the maximum mechanical strength and equilibrium swelling rate are 391.9 kPa and 59.0 g/g, respectively. The maximum antibacterial rates of E. coli and S. aureus were as high as 99.7%. Furthermore, they exhibit superior blood compatibility and no cytotoxicity as well. Most importantly, they show the ability to clot blood rapidly. This study significantly improves the comprehensive properties of chitin-derived hydrogels. It provides an important theoretical basis and technical support for its application in tissue engineering, antibacterial, and hemostatic materials. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Chemical and Process Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |