MARC details
| 000 -LEADER |
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| fixed length control field |
03942ntm a2200337 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251231105838.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
t||||fr|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251231t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010196 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FIST .A37 2025 r Thesis |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aisyah Binti Yunus, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Exploring the association of gut mycobiome composition with colorectal cancer, colorectal polyps, and healthy subjects in malaysian cohorts / |
| Statement of responsibility, etc. |
Aisyah Binti Yunus |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiv, 221 pages : |
| Other physical details |
illustrations : |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Faculty of Industrial Sciences and Technology |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Master of Science) -- Universiti Malaysia Pahang – 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Include bibliographical reference |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Colorectal cancer (CRC) is a significant public health concern and ranks among the leading causes of cancer-related mortality worldwide. Although the role of the gut microbiome in CRC development has been thoroughly investigated, the specific contribution of the gut mycobiome, particularly fungal communities, remains underexplored. This study aimed to investigate and compare the gut mycobiome composition in CRC patients, individuals with pre-CRC polyps, and healthy controls within Malaysian cohorts, and to identify potential fungal biomarkers for CRC detection. Biopsy samples from 77 subjects underwent high-throughput amplicon sequencing targeting the ITS1 region. Genomic DNA extraction yielded concentrations ranging from 12.2 to 80.5 ng/μL, with an average of 41.29 ng/μL. Taxonomic profiling revealed a comprehensive analysis of fungal taxa at both the phylum and genus levels. Among all groups, Ascomycota and Basidiomycota were identified as the most prevalent phyla. At the genus level, Mortierella was abundant in polyp patients, while Aspergillus was more prevalent in CRC patients. Saitozyma was more prevalent in healthy individuals compared to CRC and polyp patients. Alpha-diversity analysis using the Chao1 index revealed significant differences in fungal richness across the CRC, polyp, and healthy groups (p < 0.05), indicating an impact of disease status on gut fungal diversity. Betadiversity analysis demonstrated distinct fungal compositions across the cohorts, though the differences were not statistically significant (p > 0.05), suggesting the influence of additional contributing factors. LEfSe analysis identified H. werneckii as a potential fungal marker for CRC patients, while other taxa, such as Saitozyma podzolica, Aspergillus versicolor, S. etchellsii, V. victoriae, Zopfiella sp., P. niemeijerarum, U. isabellina, E. thailandicum, and L. cordylinicola, were associated with healthy individuals. Additionally, dietary intake analysis revealed that CRC patients had the highest protein intake, exceeding the Recommended Nutrient Intake (RNI). A correlation was observed between dietary patterns and the prevalence of specific fungal taxa, indicating a possible interaction between diet and gut fungal composition. Despite providing novel insights into the role of gut mycobiome in CRC pathogenesis, this study has several limitations which include the use of a cross-sectional design, a relatively small sample size, and reliance on amplicon sequencing, limiting functional interpretation. Further research should focus on expanding the sample size and employing functional assays to explore the mechanistic roles of key fungal species in CRC development. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
Faculty of Industrial Sciences and Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |