MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04725ntm a2200337 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20260216163544.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
|---|
| fixed length control field |
t||||fr|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
260216t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
THE0010338 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKKP .A45 2025 r Thesis |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nurul Aliaa Binti Abdul Rahman, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Optimization of ferulic acid recovery from mixed culture fermentation broth using task specific ionic liquids / |
| Statement of responsibility, etc. |
Nurul Aliaa Binti Abdul Rahman |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xvi, 163 pages : |
| Other physical details |
illustration ; |
| Dimensions |
30 cm.+ |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Faculty of Chemical and Process Engineering Technology |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang Al Sultan Abdullah - 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Include bibliographical reference |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Ferulic acid (FA) has garnered significant attention in various industries due to its antioxidant, antimicrobial, anti-inflammatory, and anti-thrombosis properties. Despite its valuable applications in the food, cosmetics, and pharmaceutical sectors, the efficient recovery of FA from fermentation broth remains challenging. This difficulty arises due to the presence of complex fermentation media, which includes proteins, sugars, and other organic compounds that hinder the selective separation of FA, resulting in low purity and extensive downstream processing. Moreover, conventional solvent extraction methods often involve the use of volatile organic solvents, posing environmental and safety concerns. Therefore, optimizing FA recovery from mixed culture fermentation broth is essential. To address these challenges, greener alternatives such as ionic liquids (ILs) have gained attention due to their tuneable properties, negligible vapor pressure, and enhanced selectivity for bioactive compounds. In particular, ILs function as designer solvents in liquid–liquid extraction systems, where their unique cation–anion combinations facilitate targeted interactions with specific solutes. In the case of FA, ILs enhance extraction efficiency primarily through hydrogen bonding interactions between the IL anions and the hydroxyl and carboxyl groups of FA, thereby increasing solubility and selectivity during phase separation. In this study, ILs were employed as alternative solvents in liquid–liquid extraction to improve FA recovery from fermentation broth. However, there is limited research on identifying the most effective ILs for FA recovery from fermentation broth. This study aimed to optimize FA recovery using task-specific ionic liquids (TSILs). The initial step involved screening potential ILs for FA recovery using the Conductor-like Screening Model for Real Solvents (COSMO-RS) software. The findings revealed that FA's hydrogen bond acceptor properties play a crucial role in enhancing recovery efficiency, with smaller alkyl chains and specific anion pairings such as [BF4] and [F] improving FA selectivity, capacity, and performance index. The two ILs with the highest performance index namely morpholinium tetrafluoroborate ([MOR][BF4]) and imidazolium hydrogen sulfate ([IM][HSO4]) were selected for further study, synthesized, and validated through Fourier Transform Infrared Spectroscopy and Nuclear Magnetic Resonance Spectroscopy analyses. Among them, [IM][HSO₄] exhibited higher antimicrobial activity and enzyme inhibition, whereas [MOR][BF₄] demonstrated lower toxicity, making it a more suitable solvent for biocompatible recovery. Optimization of FA recovery using [MOR][BF4] via Central Composite Design (CCD) achieved a 92.55% FA recovery rate under optimal conditions: a phase ratio of 1:5, recovery time of 45 minutes, inorganic salt concentration of 0.06M, at 45°C and pH 9.5. This optimization resulted in a 2.3% increase in FA recovery efficiency and a 15 minute reduction in recovery time compared to initial screening results. In conclusion, this study demonstrates that [MOR][BF₄] serves as a sustainable, low-toxicity, and highly efficient IL solvent for liquid–liquid extraction of FA from complex fermentation media. The results provide a valuable foundation for scalable FA recovery processes in industrial bioprocessing applications, promoting both environmental and economic benefits. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
Faculty of Chemical and Process Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |