MARC details
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03385ntm a2200337 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20260303131916.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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c| |||||||a |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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260303t20252025my a|||fs|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010413 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FIST .S939 2025 r Bc. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Nurul Syazana Aqila Binti Muhammad Zawawi, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
In silico characterization of selected orchids’ hmg-coa reductases / |
| Statement of responsibility, etc. |
Nurul Syazana Aqila Binti Muhammad Zawawi |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xiii, 116 pages : |
| Other physical details |
illustrations ; |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Industrial Sciences and Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
HMG-CoA reductase (HMGR) was an essential enzyme for producing mevalonate, a key component of floral scent in orchids. It acted as a catalyst in the mevalonate pathway. This process yielded various isoprenoid compounds, including those contributing to the floral aroma. This study investigated the structure and function of HMGR and its homologous proteins in five orchid species which were Vanda Mimi Palmer, Phalaenopsis equestris, Dendrobium nobile, Dendrobium catenatum, and Vanilla planifolia, using an in silico approach.Amino acid sequences available in the NCBI GenBank were utilized to perform homology modeling and predict the threedimensional (3D) structures of HMGR and its related proteins. The reliability of these structural models was validated using VERIFY 3D, PROCHECK, and ERRAT tools. The study aimed to predict the 3D-protein structure of the selected orchids' HMG-CoA reductases and homologous proteins using a homology modeling approach and to investigate the binding positions of potential ligands to the 3D structure of these enzymes by molecular docking. Active pocket regions (R1 and R2) were identified using CASTp, where R1 was the predicted pocket binding site of the selected orchid HMGRs and homologous proteins, while R2 was the predicted pocket binding site for 8ECG. Molecular docking experiments were conducted to evaluate the binding sites and affinities of potential substrates (HMG-CoA, Acetyl-CoA, and Acetoacetyl-CoA) and their product, mevalonate. Protein-ligand docking studies were performed using Autodock Vina to predict the orientation of a ligand bound to the protein and compare it with the predicted active site pocket analysis. This study contributed to a deeper understanding of the molecular and functional properties of HMGR and its homologous proteins in orchids. These insights enhanced knowledge of floral scent biosynthesis, particularly the enzymatic pathways involving HMG-CoA reductases, and provided valuable information for potential applications in horticulture, the fragrance industry, and related fields |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Industrial Sciences and Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Final Year Report |
| General subdivision |
Dissertations |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
http://umpir.ump.edu.my/id/eprint/45761 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |