MARC details
| 000 -LEADER |
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| fixed length control field |
03274ntm a2200349 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20260421124755.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
t||||fr|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
260421t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010487 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FIST .J53 2025 r Bc. |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Ong, Jia Xian, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and docking simulation of 2- benzoylcyclohexanon e for potential colon cancer treatment / |
| Statement of responsibility, etc. |
Ong Jia Xian |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiv, 72pages : |
| Other physical details |
illustrations ; |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Faculty of Industrial Sciences and Technology |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Final Year Report (Bachelor of Applied Science of Industrial Chemistry) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Include bibliographical reference |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality globally, emphasizing the need for innovative therapeutic approaches. This study explores the synthesis, characterization, and molecular docking analysis of 2- benzyolcyclohexanone compound, focusing on 2-benzoylcyclohexanone as a promising potential inhibitor of the epidermal growth factor receptor (EGFR), a pivotal protein in CRC progression. The research was conducted in two phases: the first involved the synthesis of the 2-benzyolcyclohexanone compound using Stork enamine alkylation and nucleophilic substitution methods, followed by structural characterization using Fouriertransform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. FTIR analysis revealed characteristic carbonyl peaks at 1710.51 cm⁻¹ and 1683.10 cm⁻¹, confirming the 2-benzyolcyclohexanone structure. The 1H proton NMR spectrum exhibited aromatic signals between 1.773 and 4.335 ppm, further validating the compound's structure. In the second phase, molecular docking simulations were performed using SwissDock to investigate binding interactions with EGFR. The synthesized 2-benzyolcyclohexanone demonstrated moderate binding affinity (binding energy: -4.824 kcal/mol) compared to Fruquintinib (-5.398 kcal/mol) and AQ4 (-4.895 kcal/mol). Key interactions included hydrophobic forces and π-stacking, which are critical for receptor inhibition. Despite a slightly lower binding affinity than standard inhibitors, 2-benzoylcyclohexanone exhibits significant potential as a lead compound due to its 2-benzyolcyclohexanone scaffold, which serves as an excellent starting point for further optimization.This study establishes a foundation for the development of accessible and cost-effective CRC treatments. Future directions include in vitro cytotoxicity assays, structure-activity relationship (SAR) studies, and in vivo testing to enhance the compound's efficacy and safety profile. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Industrial Sciences and Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
https://umpir.ump.edu.my/id/eprint/46139 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Final Year Report |