MARC details
| 000 -LEADER |
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| fixed length control field |
04145ntm a2200349 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20260714173657.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
t|||||r|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
260714t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010733 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKKP .M395 2025 r Bc. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maziah Binti Zakaria, , , |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Formulation of quercetin tablet : |
| Remainder of title |
enhancing solubility with microcrstalline cellulose / |
| Statement of responsibility, etc. |
Maziah Binti Zakaria |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiii, 44 pages : |
| Other physical details |
illustrations ; |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Faculty of Chemical and Process Engineering Technology |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Include bibliographical reference |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
This thesis presents the formulation and evaluation of quercetin supplement tablets utilizing microcrystalline cellulose (MCC) as a primary excipient. Quercetin, a flavonoid with significant antioxidant properties, has garnered attention for its potential health benefits, including anti-inflammatory and anti-cancer effects. The objective of this study was to investigate the effect of microcrystalline cellulose on the formulation of quercetin tablets on the physical and mechanical properties of quercetin tablets. The formulation process involved the selection of appropriate excipients, with MCC chosen for its excellent binding and compressibility properties. Various formulations were prepared and subjected to rigorous testing, including pre-formulation studies, tablet compression, and post-compression evaluations. The methodology involved several key steps, beginning with the preparation of raw materials, where quercetin powder, MCC, starch, and magnesium stearate were carefully weighed and prepared to ensure uniformity and compatibility. Pre-formulation experiments were conducted to assess the physical characteristics of quercetin and its compatibility with excipients, leading to the creation of a mixture of quercetin, starch, and varying concentrations of MCC (7%, 10%, 13%, 17%, and 20%), followed by the addition of magnesium stearate as a lubricant. The mixture underwent wet granulation, sieving, and drying to form granules, which were then compressed into tablets using a tablet press machine. Rigorous quality control tests were performed on the tablets, including friability, hardness, weight variation, disintegration, and dissolution tests. The results indicated that varying concentrations of MCC significantly influenced the mechanical properties and dissolution profiles of the quercetin tablets. In friability testing, an increase in MCC content generally improved tablet strength, although a peak was observed at 13% MCC, where friability exceeded acceptable limits. Hardness testing revealed that the hardness of tablets increased with MCC concentration up to 10%, after which it declined, suggesting an optimal range for MCC to enhance tablet integrity. Weight variation analysis showed that the weight of the tablets varied with MCC concentration, indicating that higher MCC levels contributed to better compaction and uniformity. Disintegration times decreased with increasing MCC concentrations, particularly at 17%, which also exhibited the fastest dissolution rate, indicating improved bioavailability of quercetin. Overall, the study successfully demonstrated that MCC plays a crucial role in optimizing the formulation of querceti tablets, balancing mechanical strength and dissolution properties to enhance the therapeutic efficacy of the supplement. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
Faculty of Chemical and Process Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
https://umpir.ump.edu.my/id/eprint/47617 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Final Year Report |