Optimizing risk management strategies for reverse osmosis in pharmaceutical purified water systems through enhanced integration of machine learning and quantitative risk assessment / (Record no. 105304)

MARC details
000 -LEADER
fixed length control field 03603ntm a2200349 i 4500
003 - CONTROL NUMBER IDENTIFIER
control field MY-KuUP
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20260727100319.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
fixed length control field t|||||r|||| 000 0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field ta
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 260727t20252025my a|||fr|||| 000 0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number THE0010762 (Local)
Qualifying information Hardback
040 ## - CATALOGING SOURCE
Original cataloging agency UMPSA
Language of cataloging eng
Transcribing agency UMPSA
Description conventions rda
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) FTKKP .S63 2025 r Bc.
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Soddiki Sylvester Bin Theobold, , ,
Relator term author.
245 10 - TITLE STATEMENT
Title Optimizing risk management strategies for reverse osmosis in pharmaceutical purified water systems through enhanced integration of machine learning and quantitative risk assessment /
Statement of responsibility, etc. Soddiki Sylvester Bin Theobold
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Kuantan, Pahang :
Name of producer, publisher, distributor, manufacturer UMPSA,
Date of production, publication, distribution, manufacture, or copyright notice 2025
264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice © 2025
300 ## - PHYSICAL DESCRIPTION
Extent xi, 66 pages :
Other physical details illustrations ;
336 ## - CONTENT TYPE
Source rdacontent
Content type term text
337 ## - MEDIA TYPE
Source rdamedia
Media type term unmediated
338 ## - CARRIER TYPE
Source rdacarrier
Carrier type term volume
347 ## - DIGITAL FILE CHARACTERISTICS
Source rda
File type text file
Encoding format PDF
500 ## - GENERAL NOTE
General note Faculty of Chemical and Process Engineering Technology
502 ## - DISSERTATION NOTE
Dissertation note Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceutical) with Hons.) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc. note Include bibliographical reference
520 3# - SUMMARY, ETC.
Summary, etc. With the emergence of the Fourth Industrial Revolution (IR 4.0), more industries, like the pharmaceutical industry, are focusing on digital technologies that can add efficiency and reliability to their process, such as reverse osmosis (RO) in purified water systems. This study investigates the integration of machine learning (ML) with quantitative risk assessment (QRA) as tools to optimize RO processes in pharmaceutical purified water systems. The main objectives of this study were to apply a multivariable mathematical model, integrate QRA with ML techniques, and validate the predictive models with QRA outputs. The study followed a systematic methodology to achieve its objectives. Firstly, critical process parameters (CPP) were identified using the multivariable mathematical model, followed by data simulation with @RISK software. The Friday 13th (Fr 13) framework was implemented using Monte Carlo simulations to identify unexpected failures. 10,000 iterations were generated from @RISK to evaluate the distribution of risk factors. The data was then imported into RapidMiner for ML analysis to create predictive models. The ML approach used Random Forest ML algorithms to improve risk prediction and classification. The dataset was split into training (70%) and testing (30%) subsets to ensure robust model validation. The analysis, which included 10,000 data points and represents 100% of the dataset, showed a failure rate of 20.8% for @RISK and 20.82% for RapidMiner. The results showed a slight difference (0.02%) in the risk of failure, demonstrating it accuracy of the predictive models. The integration of ML improved predictive accuracy, with the Random Forest model identifying risk factors with a high classification performance (97.8%). These results demonstrate the accuracy of the developed machine learning model and its potential for accurate risk assessment in RO systems. To conclude, the integration of ML and QRA provides a reliable and efficient approach to risk assessment in pharmaceutical RO systems. These results highlight the potential of ML to automate risk analysis and optimize operational performance.
610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Chemical and Process Engineering Technology
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Universities and colleges
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Theses
General subdivision Dissertations
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier https://umpir.ump.edu.my/id/eprint/47706
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Library of Congress Classification
Koha item type Final Year Report
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
  Not lost Library of Congress Classification     UMPLIB GAMBANG UMPLIB GAMBANG 27/07/2026   FTKKP .S63 2025 r Bc. T000004356 27/07/2026 27/07/2026 Final Year Report

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