MARC details
| 000 -LEADER |
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| fixed length control field |
03651ntm a2200349 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20260727101813.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| fixed length control field |
t|||||r|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
260727t20252025my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010763 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKKP .U45 2025 r Bc. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Umie Umaira, , , |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
The influence of stirring position on the product properties of carbamazepine-saccharin co-crystal / |
| Statement of responsibility, etc. |
Umie Umaira |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2025 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xii, 32 pages : |
| Other physical details |
illustrations ; |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Chemical and Process Engineering Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceutical) with Hons.) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Include bibliographical reference |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Carbamazepine (CBZ) is a widely used drug for the treatment of epilepsy and neuropathic pain; however, its poor solubility and polymorphic behavior limit its therapeutic effectiveness. One promising strategy to enhance its solubility and stability is through co-crystallization with saccharin (SAC). This study investigates the impact of stirrer position on the crystallization and quality of CBZ-SAC co-crystals using a batch cooling crystallization method. The stirrer height was varied at 10 mm, 20 mm, and 30 mm from the bottom of the crystallizer to evaluate its effect on nucleation, crystal morphology, and overall co-crystal formation. The synthesized co-crystals were analyzed using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and particle size analysis to determine their structural integrity and thermal stability. The results revealed that stirrer position significantly influenced crystal formation and quality. A stirrer height of 10 mm resulted in irregular crystal morphology due to inadequate mixing and localized supersaturation, while a height of 30 mm caused excessive turbulence, leading to fragmented and mechanically stressed crystals. The optimal stirrer height was found to be 20 mm, producing uniform, well-defined crystals with enhanced thermal and structural stability. FTIR analysis confirmed the formation of strong hydrogen bonding interactions between CBZ and SAC, while XRD validated the crystalline nature of the co-crystals. Additionally, DSC analysis demonstrated improved thermal stability, reinforcing the pharmaceutical viability of the optimized co-crystals. These findings underscore the importance of optimizing stirring conditions in pharmaceutical crystallization to enhance drug solubility, stability, and overall performance. The results provide valuable insights into improving the co-crystallization process for pharmaceutical applications. Further research is recommended to explore additional process parameters such as solvent selection, cooling rates, and stirring speeds, as well as to evaluate the scalability of this approach for industrial applications. By refining crystallization techniques, this study contributes to the development of more effective and reliable drug formulations. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Chemical and Process Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Theses |
| General subdivision |
Dissertations |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
https://umpir.ump.edu.my/id/eprint/47705 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Final Year Report |