MARC details
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| 003 - CONTROL NUMBER IDENTIFIER |
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MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20261006114618.0 |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
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261006t20262026my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0010816 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMPSA |
| Language of cataloging |
eng |
| Transcribing agency |
UMPSA |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKPM .A23 2026 r Thesis |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Abbas Shabudin, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Investigating brain oedema formation in ischaemic stroke using poromechanics and multiscale modelling / |
| Statement of responsibility, etc. |
Abbas Shabudin |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMPSA, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2026 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
ยฉ 2026 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xvii, 136 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-COM |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Manufacturing and Mechatronic Engineering Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang โ 2026 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
This research investigates the estimation of effective poroelastic properties of brain tissue with particular emphasis on the role of capillary networks in cerebrovascular diseases such as ischaemic stroke. Brain oedema following iscahemic stroke leads to tissue swelling and increased intracranial pressure (ICP), which can result in severe neurological damage. Existing models often treat brain tissue as a homogenous material with uniform properties, neglecting the complex microvascular structure that governs fluid transport and mechanical response. Therefore, there is a need to remodel brain oedema formation by incorporating microscale capillary morphology to obtain more physiologically realistic predictions. A multiscale modelling framework based asymptotic expansion homogenization (AEH) is employed to estimate effective parameters governing brain tissue mechanics and fluid transport. These include the effective blood hydraulic conductivity tensor (๐ฒ), interstitial fluid hydraulic conductivity tensor (๐ฎ), Biotโs coefficients for blood (๐ผ๐) and interstitial fluid (๐ผ๐ก), and the effective Youngโs modulus ( ๐ธฬ
) and Poissonโs ratio (๐ฃฬ
). This study aims to (i) analyse the influence of capillary morphology using idealized microstructures, (ii) estimate and validate effective properties using data-driven capillary distributions, and (iii) apply the derived parameters to simulate brain tissue swelling at the macroscale under ischaemic conditions. Microscale analysis show that capillary tortuosity significantly reduces ๐ฒ and affects ๐ผ๐, while capillary radius influences all effective parameters. Data-driven microstructures were reconstructed from statistical capillary distributions and adapted to satisfy periodicity requirements for homogenization. Numerical implementation was carried out using finite element analysis within the AEH framework, where geometric modifications introduce changes in the representative volume element that may influence certain effective parameters. Validation against Poiseuille-based formulations demonstrates that the predicted blood conductivity remains within the same order of magnitude, confirming the consistency of the model. Macroscale simulations reveal that variations in capillary tortuosity and radius significantly influence interstitial fluid pressure (๐๐ก), blood pressure (๐๐) and tissue displacement (๐ข), capturing key features of brain oedema such as pressure gradients and swelling. The model also demonstrates that incorporating microscale capillary effects can be achieved with significantly reduced computational complexity compared to fully resolved models. The scientific novelty of this work lies in the integration of data-driven capillary morphology with a complete set of poroelastic effective parameters within a unified multiscale homogenization framework, together with a systematic sensitivity analysis of microstructural features. This contributes to the Body of Knowledge (BoK) in computational biomechanics, multiscale modelling of porous biological media, and poroelastic modelling of brain tissue. Practically, the proposed framework provides a foundation for patient-specific modelling, prediction of oedema progression, and potential clinical decision support in cerebrovascular disease management. Despite its contributions, the model assumes linear elastic tissue behavior, Newtonian blood flow, and periodic microstructures, which may limit quantitative accuracy. Nevertheless, it provides a robust and computationally efficient framework for capturing the dominant effects of microvascular morphology on brain tissue response. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Manufacturing and Mechatronic Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Thesis |
| General subdivision |
Dissertations |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |