MARC details
| 000 -LEADER |
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| fixed length control field |
03191nam a2200253 a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000067880 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251114204523.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
121220t2012 my da f m 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0002460(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
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| Level of rules in bibliographic description |
201905271529 |
| Level of effort used to assign nonsubject heading access points |
shamsul |
| -- |
201212201154 |
| -- |
Fida |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
TA418.9.F5 M84 2012 rs Bc. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Mohamad Muhaimin Zalani |
| 245 10 - TITLE STATEMENT |
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| Title |
Encapsulation of therapeutic protein within polymeric nanofiber using co-axial electrospinning / |
| Statement of responsibility, etc. |
Mohamad Muhaimin Zalani |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Kuantan, Pahang : |
| Name of publisher, distributor, etc. |
UMP, |
| Date of publication, distribution, etc. |
2012 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiv, 68 p. : |
| Other physical details |
ill. (some col.) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Project paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2012 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: p. 59-62 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
A drug delivery system is designed to provide a therapeutic agent in the needed amount, at the right time and to the proper location in the body in a manner that optimizes the efficacy, increases compliance and minimizes side effects. In order to study the encapsulation of therapeutic protein within polymeric nanofiber for controlled release using co-axial electrospinning method, a number of main processing parameters were taken into considerations which are formulation of drug loading, polymer and protein concentration and solution flow rate. Polymeric drug delivery device was developed via electrospinning technique using biodegradable Polymer A. Co-axial electrospinning configuration was used to encapsulate various mixtures of Drug 0066, Drug 0360 and also Polymer B as support into the electrospun nanofibers. Using the configuration, two separate solutions flowed through two different capillaries and electrospun through co-axial nozzle configuration setup. The electrified jet will undergo stretching, leading to formation of long and thin thread. When the liquid jet is continuously elongated, the solvent will evaporate. The grounded collector will attract the charged fiber. The morphology of the electrospun nanofibers were analyzed using Field Emission Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM). The hydrophilicity of electrospun nanofibers were determined using Surface Contact Angle machine. Fourier Transform Infrared Spectrometry (FT-IR) was used to detect the organic group of the electrospun nanofibers. In vitro release studies were conducted to evaluate sustained release potential of the core-sheath structure composite nanofiber. The results showed that the TEM images clearly proved the core/shell structure of nanofibers for the encapsulation of Drug 0066/Drug 0350 within Polymer A. SEM also showed there was an arch appeared within the nanofiber. The present study would provide a basis for further design and optimization of processing conditions to control the nanostructure of core-sheath composite nanofibers and ultimately achieve desired release kinetics of bioactive proteins (e.g., growth factors) for practical tissue engineering applications. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Nanofibers |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Electrospinning |