MARC details
| 000 -LEADER |
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| fixed length control field |
02736ntm a2200241 a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000083380 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251117113235.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
141112t2013 my a f m 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0004113(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
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| Level of rules in bibliographic description |
201905131409 |
| Level of effort used to assign nonsubject heading access points |
farhana |
| Level of effort used to assign subject headings |
201411131501 |
| Level of effort used to assign classification |
ariffin |
| -- |
201411121713 |
| -- |
ariffin |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
TP156.F4 A87 2013 r Bc. |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Mohamed Asshafie Mohamed Sharif |
| 245 10 - TITLE STATEMENT |
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| Title |
Solid phase transformation of carbamazepine-fumaric acid cocrystal / |
| Statement of responsibility, etc. |
Mohamed Asshafie Mohamed Sharif |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Kuantan, Pahang : |
| Name of publisher, distributor, etc. |
UMP, |
| Date of publication, distribution, etc. |
2013 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xv, 64 p. : |
| Other physical details |
ill. (some col.) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Project paper (Bachelor of Chemical Engineering -- Universiti Malaysia Pahang – 2013 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography : p. 49-51 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The study is about the solid phase transformation of carbamazepine-fumaric acid co-crystal. Pharmaceutical area is the most importance part in human live. In pharmaceutical, the solubility of the active pharmaceutical ingredients (API) is importance physical property to be studied. Co-crystal formation is an example method to improve the solubility of an API. Carbamazepine is an API which has low solubility. In this study carbamazepine and fumaric acid are used to form co-crystal in ethanol as a solvent. The objective of this research is to study the solid phase transformation of carbamazepine-fumaric acid cocrystal. Initially the solubility of the carbamazepine is measured using gravimetric and High Performance Liquid Chromatography (HPLC). Later, the co-crystal transformation study will be proceed via varying the ratio of fumaric acid to carbamazepine using slurry method. Carbamazepine and fumaric acid are characterized using Thermal Gravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). The result shows the solubility of carbamazepine and fumaric acid increased as temperature increased. The Fourier Transform Infrared Spectroscopy (FTIR) spectrums show the main spectrum frequency (absorption region in cmˉ¹) for carbamazepine and fumaric acid. Thermo Gravimetric Analysis (TGA) analysis showed the total decomposition for carbamazepine is approximately at 250 °C and for the fumaric acid at 260 °C. As the conclusion the solubility of carbamazepine and fumaric acid has been increased as the temperature increased. Due to the time constraints and the technical failure of the equipment (High Performance Liquid Chromatography (HPLC)) during the analysis has resulted the cocrystal transformation study could not be completed. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pharmaceutical biotechnology |