MARC details
| 000 -LEADER |
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| fixed length control field |
04483ntm a2200289 a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000099669 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251117113326.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170502t2016 my da f am 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0000130(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
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| Level of rules in bibliographic description |
201905131237 |
| Level of effort used to assign nonsubject heading access points |
nazirah |
| Level of effort used to assign subject headings |
201710041229 |
| Level of effort used to assign classification |
aishah |
| -- |
201705021030 |
| -- |
saini |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FIST .C43 2016 r Thesis |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Chahal, Sugandha |
| 245 10 - TITLE STATEMENT |
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| Title |
Electrospun hydroxyethyl cellulose nanofibrous scaffolds functionalized with hydroxyapatite for bone tissue engineering / |
| Statement of responsibility, etc. |
Sugandha Chahal |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Kuantan, Pahang : |
| Name of publisher, distributor, etc. |
UMP, |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xx, 159 p. : |
| Other physical details |
ill. (some col.) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Industrial Science & Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Doctor of Philosophy in Advanced Materials) -- Universiti Malaysia Pahang – 2016 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography : p. 124-156 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Bone tissue engineering focuses on using scaffolds as vital substitute to regenerate the bone structure and therefore recover the function of bone tissue. Selection of the suitable material is an important step towards the construction of bioactive engineered scaffolds with appropriate surface architecture, biocompatibility, biodegradability and biomechanical properties that can mimic the natural bone extracellular matrix (ECM). The main aim of this research is to prepare bio-compatible and biodegradable scaffolds based on hydroxyethyl cellulose (HEC) using water as the only solvent. The biochemically and functionally designed nanofibrous scaffolds of HEC polymer with polyvinyl alcohol (PVA) were prepared by electrospinning technique. HEC was blended with PVA in various weight concentrations to get a suitable viscosity for electrospinning. For functionalization of HEC/PVA nanofibers, the nanohydroxyapatite (nHA) particles were synthesized and then reinforced in HEC/PVA scaffolds through electrospinning. Furthermore, bio-mineralization of HEC/PVA scaffolds was performed using simulated body fluid (SBF) and alternate calcium phosphate (ACP) soaking process to mimic ECM. The cytocompatibility of unmineralized and mineralized scaffolds was evaluated by in-vitro cell culture studies. Scanning electron microscopy and Field emission scanning electron microscopy were used for structural analysis. Mechanical properties were investigated by Universal testing machine. Energy dispersive X-ray, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, Thermo-gravimetric analysis, Differential scanning calorimetery and Dynamic mechanical analysis were used to analyse chemical, and thermal properties of scaffolds. The prepared nanofibrous scaffolds exhibit excellent morphology with interconnected porous structure. Changing HEC concentration had great influence on the structure and properties of the scaffolds. With increasing HEC concentration, the fiber diameter decreased and pore size increased. The diameters of electrospun nanofibrous scaffolds varied in the range of 379 nm to 524 nm and the pore sizes varied from 9 μm to 6 μm.The results revealed that the biocompatible HEC/PVA scaffolds possess good mechanical and chemical properties. The rod like nHA particles with chemical composition of natural bone minerals was successfully prepared by wet chemichal method. The results confirmed the reinforcement of nHA patricles in HEC/PVA electrospun nanofibers. Coating of mineral cystals was found on the surface of scaffolds after bio-mineralization. The deposition of biomimetic minerals increased with time of immersion in SBF and nHA deposition was found to increase with high content of HEC during ACP soaking process. The influence of biomineralization was observed with improved bioactivity and mechanical properties of the scaffolds. The enhancement in properties after mineralization could be due to the presence of mineral particles on nanofibrous scaffolds which allows the penetration and migration of cells and provides good mechanical strength with strong chemical interaction. These results suggest that the HEC/PVA scaffolds are promising biomaterials for bone tissue engineering. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Industrial Science & Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and Colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Theses |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://ecollib.ump.edu.my/25924/">http://ecollib.ump.edu.my/25924/</a> |
| Public note |
Library access only |