Enhancement of ring and ripple microelectrodes design using dielectrophoresis (DEP) for biochip application / (Record no. 7742)

MARC details
000 -LEADER
fixed length control field 04748ntm a2200361 i 4500
001 - CONTROL NUMBER
control field vtls000104346
003 - CONTROL NUMBER IDENTIFIER
control field KUKTEM
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251117113401.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180723s2018 my a f a m 000 0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number THE0005200(Local)
039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE]
Level of rules in bibliographic description 201905141447
Level of effort used to assign nonsubject heading access points hanafiah
Level of effort used to assign subject headings 201905141446
Level of effort used to assign classification hanafiah
Level of effort used to assign subject headings 201808131531
Level of effort used to assign classification fateeha
-- 201807231014
-- fateeha
040 ## - CATALOGING SOURCE
Original cataloging agency UMP
Language of cataloging eng
Transcribing agency UMP
Description conventions rda
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) FKEE .N877 2018 r Thesis
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Siti Nursyahirah Ahmad Latfi,
Relator term author.
245 10 - TITLE STATEMENT
Title Enhancement of ring and ripple microelectrodes design using dielectrophoresis (DEP) for biochip application /
Statement of responsibility, etc. Siti Nursyahirah Ahmad Latfi
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Kuantan, Pahang :
Name of producer, publisher, distributor, manufacturer UMP,
Date of production, publication, distribution, manufacture, or copyright notice 2018
300 ## - PHYSICAL DESCRIPTION
Extent xiv, 107 pages :
Other physical details illustrations (some color) ;
Dimensions 30 cm. +
Accompanying material 1 CD ROM
336 ## - CONTENT TYPE
Content type term text
Source rdacontent
336 ## - CONTENT TYPE
Content type term text
Source rdacontent
337 ## - MEDIA TYPE
Media type term unmediated
Source rdamedia
337 ## - MEDIA TYPE
Media type term computer
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term volume
Source rdacarrier
338 ## - CARRIER TYPE
Carrier type term computer disc
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
500 ## - GENERAL NOTE
General note Faculty of Electrical and Electronics Engineering
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Master of Science) -- Universiti Malaysia Pahang – 2018
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc. note Includes bibliographical references
520 3# - SUMMARY, ETC.
Summary, etc. Nowadays, the need for the analysis of biological cells has become a platform for researchers to develop related technologies and devices for conducting appropriate manipulation such as trapping, screening, and sorting. This is because the analysis of biological cells can be beneficial to better understand the properties of biological cells and find the solution and treatment in medical applications. Various manipulation techniques have been developed to manipulate biological cells such as manipulation technique in chemical, mechanical, acoustic and electric fields. The DEP was force used to manipulate the cells resulting from the generation of a non-uniform AC electric field and electrode patterns play a major role in producing the required electric field. The current design has limitations in terms of the distribution pattern of the electric field generated and insufficient simulation data required for the development of biochip. There were two new electrodes which are ring pattern microelectrode and ripple pattern microelectrode developed in this study. The main objective of this work is to investigate the electric field distribution resulted from the microelectrodes. All analyses performed in this study were based on simulations. Simulations were carried out by using COMSOL Multiphysics software, which provides suitable simulation and analysis platform for this study. The optimisation of an electrode was done by making some modifications to the dimensions of the electrodes and simulated with different electrical potential values. This was done to improve the performance of the electrodes to trap a single cell. Based on the simulation results obtained, the highest strength of the electric field distribution was generated by the ring electrode pattern 5.22  106 V/m produced and the DEP force was 1.42  10-13N. The ripple pattern electrode generated 2.04  107 V/m of electric field and the DEP force produced was 4.19  10-11 N which was higher than the ring electrode. It was found that the temperature rise issues can be controlled based on simulation results by reducing the voltage by half, yet electric field can generate higher electric field strength. The percentage increase in electric field strength of ring microelectrode and ripple microelectrode was 86.86% and 47.55%, respectively. The results showed that the distance between the microelectrodes and micro-cavity provided more impact in electrical field distribution strength compared to the change of the microelectrodes dimension. The resulting electrical field strength was high between the microelectrodes tip and edge of the micro-cavities. Cell trapping may also occur in the central part of the micro-cavities with nDEP where the cells were attracted to the areas of low electric field. On the other hand, when pDEP was used, cells were attracted to the edge of micro-cavities where the high electric field region occurred. With the simulation and analysis obtained, designed microelectrode was able to trap the cells. This research work became an attempt to find a biochip design, in order to get the better electrode design patterns which offered higher efficiency in manipulating and trapping the biological cells.
610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Electrical and Electronics Engineering
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Universities and colleges
General subdivision Disertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Theses
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Date acquired Total checkouts Full call number Barcode Date last seen Copy number Price effective from Koha item type
  Not lost Library of Congress Classification   Not for loan UMPLIB PEKAN UMPLIB PEKAN 04/09/2019   FKEE .N877 2018 r Thesis 0000123606 04/09/2019 1 04/09/2019 Thesis
  Not lost Library of Congress Classification   Not for loan UMPLIB PEKAN UMPLIB PEKAN 04/09/2019   CD 11395 | FKEE .N877 2018 r Thesis 0000123607 04/09/2019 1 04/09/2019 Thesis

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