MARC details
| 000 -LEADER |
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| fixed length control field |
03020ntm a2200349 i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000103695 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251117113403.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180531s2018 my a f am 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0001349(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
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| Level of rules in bibliographic description |
201905141228 |
| Level of effort used to assign nonsubject heading access points |
asmadi |
| -- |
201805311452 |
| -- |
saini |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTeK .G36 2018 r Bc. |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Gan, Zun Jia, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Statistical analysis of factors affecting monoclonal antibody production by using principal component analysis : |
| Remainder of title |
molecular markers / |
| Statement of responsibility, etc. |
Gan Zun Jia |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMP, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xi, 65 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
unmediated |
| Source |
rdamedia |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
computer disc |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Engineering Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Project Paper (Bachelor Of Manufacturing Engineering Technology (Pharmaceutical) -- Universiti Malaysia Pahang – 2018 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The increasing demand for the monoclonal antibodies creates an urge for the biopharmaceutical industry to select high producing cell lines for maximum product concentration in order to cope with the market demand. The development of such cell line is a lengthy and challenging process. However, cell line with high productivity can be predicted by determining the early markers which will significantly minimize the time required to develop new cell line. This study focuses on the molecular markers in the antibody secretion pathway of a panel of six Chinese Hamster Ovary (CHO) stable cell lines which producing recombinant monoclonal antibodies at different rates, ranging between 2 and 50 pg/cell/day. The correlation between the selected molecular parameters and specific productivity (qp) of the cell lines throughout the exponential phase of batch cultures was studied by analyzing the results statistically using Principal Component Analysis (PCA) in STATISTICA 10. The data was arranged and analyzed according to the cell lines and the days in growth phase of the batch cultures. This study revealed that cell line 47 and cell line 76 had greater influences on the specific productivity than the other cell lines and intracellular heavy chain (HC) showed the strongest positive correlation with the specific productivity of the cell line. Higher intracellular HC is associated with higher specific productivity. More researches on the optimization of the molecular markers especially intracellular HC shall be done to further reveal its correlation with specific productivity. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Disertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |