MARC details
| 000 -LEADER |
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| fixed length control field |
03679ntm a2200373 i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000105309 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251117113405.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180926t20182018my a f a m 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0000145(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
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| Level of rules in bibliographic description |
201905131419 |
| Level of effort used to assign nonsubject heading access points |
nazirah |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FIST .H35 2018 r Thesis |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Siti Noor Hajar Zamrus, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and characterization of curcuminoids by claisen-schmidt condensation and their cytotoxic effects on hela and K562 cancer cell lines / |
| Statement of responsibility, etc. |
Siti Noor Hajar Zamrus |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMP, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2018 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xviii, 117 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rdacontent |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Source |
rdamedia |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
computer disc |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Industrial Sciences and Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Master of Science) -- Universiti Malaysia Pahang – 2018 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Cancer is one of leading causes of death worldwide with the number of cases is expected to rise by 70% over the next two decades. These facts have lead researchers to continue studying how to treat cancer by find a new potential drug to replace the standard anti-cancer drugs such as doxorubicin which has side effects. Numerous natural compounds have been extensively investigated for their potential use in cancer prevention over decades. Curcumin from Curcuma longa has caught attention among researchers, is a highly promising natural compound that can potentially be used for chemoprevention of various cancers. Curcumin fulfils the characteristics for an ideal chemopreventive agent with its low toxicity, affordability and easy accessibility. But due to structurally instable, low solubility and poor bioavailability, the mono-ketone of curcuminoids were synthesized to improve its structure and poor bioavailability. About 20 curcuminoids were synthesized by using different substituted aldehydes and different ketones under Claisen-Schmidt condensation reaction method. The products were purified by using column chromatography, thin layer chromatography and crystallization processes. The chemical structures of the synthesized compounds were elucidated by using UV-VIS spectroscopy, Fourier transform infrared spectrometer (FTIR), Mass spectroscopy (MS) and Nuclear magnetic resonance spectrometer (NMR) spectroscopy. The compounds were screened for their cytotoxicity effects on HeLa human cervical carcinoma and K562 cancer cell lines by using MTT assay. Among these derivatives, 21 (IC50 = 12.50 ± 1.30), 22 (IC50 = 11.00 ± 2.80), 23 (IC50 = 9.00 ± 1.20), 26 (IC50 = 12.00 ± 1.60), 28 (IC50 = 11.00 ± 2.10), 29 (IC50 = 15.00 ± 1.60), 30 (IC50 = 15.00 ± 1.20), 31 (IC50 = 14.00 ± 1.40), 32 (IC50 = 11.00 ± 1.30), 33 (IC50 = 11.00 ± 1.20) and 34 (IC50 = 6.00 ± 1.20) showed high cytotoxic effects on HeLa human cervical carcinoma cell lines. Meanwhile, compounds 22 (IC50 = 6.50 ± 0.80), 23 (IC50 = 16.00 ± 1.30), 32 (IC50 = 15.00 ± 1.90) and 33 (IC50 = 12.50 ± 0.95) showed high cytotoxic effects against K562 cancer cell lines. Therefore, some compounds were found to show higher cytotoxicity effect against HeLa and K562 cancer cell lines in comparison to doxorubicin used as standard. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Industrial Sciences and Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |