MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03834ntm a2200373 i 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
vtls000105279 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
KUKTEM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20251117113438.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180924t20182018my a f a m 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
THE0007905(Local) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
|---|
| Level of rules in bibliographic description |
201906131049 |
| Level of effort used to assign nonsubject heading access points |
azli |
| -- |
201809241137 |
| -- |
fateeha |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FKKSA .A36 2018 r Thesis |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohd Aiman Hamdan, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Investigation of cellulose incorporated into carrageenan matrix for hard capsule process development / |
| Statement of responsibility, etc. |
Mohd Aiman Hamdan |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMP, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2018 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiv, 100 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rdacontent |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Source |
rdamedia |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
computer disc |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Faculty of Chemical and Natural Resources Engineering |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Master of Science) -- Universiti Malaysia Pahang – 2018 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Global market is highly demands for plant based capsule to replace the animal gelatin based capsule product. Previous research showed that the structure of carrageenan hard capsule was brittle and had low tensile strength. The aim of this work is to formulate and modify cellulose additive material incorporated in carrageenan hard capsule to increase the tensile strength. Filler characterization and screening were conducted among carboxymethyl cellulose (CMC), microcrystalline cellulose (MCC) and cellulose nanocrystals (CNC) at concentration from 0 to 2% w/w for CMC and MCC and w/v for CNC. These cellulose additive screening is to find the best cellulose additive to increase the tensile strength of carrageenan hard capsule. It is reported that CNC was the best filler to be incorporated in the carrageenan hard capsule. CNC was prepared using ultrasonication of MCC and the dimension and crystallinity of CNC was analyzed using transmission electron microscopy (TEM) and X-ray diffraction (XRD), respectively. Mixing time and temperature were studied to find the best condition in production of hard capsule solution. Sample films and capsules were characterized through disintegration test (DT), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Fourier transforms infrared (FTIR) spectroscopy, differential scanning calorimeter (DSC), viscosity, tensile strength, and moisture content analysis. The size of CNC ranges from 177 to 247 nm length and 53 to 74 nm width, with aspect ratio of 4.34. Three fingerprint peaks of cellulose at 2θ= 15.6°, 22.7° and 34.7° were observed in the diffractogram trend. Incorporation 1.6% of solvent free CNC increased the tensile strength of carrageenan film up to 58%. At 2.0%, tensile strength of the film reduced due to the formation of agglomeration in the film matrix as proven from film cross section morphology analysis. However, addition of CNC in formulation solution did not significantly change the thermal stability of the film. In addition, the hard capsule disintegrated in less than 15 minutes and fulfilled for drug delivery application. Manipulation of mixing time and temperature shows that as the time and temperature increased, the viscosity and tensile strength of Carra-CNC1.6 solution and film respectively were increased due to loss of water in the formulation solution. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
Faculty of Chemical & Natural Resources Engineering |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Disertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |