MARC details
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| 003 - CONTROL NUMBER IDENTIFIER |
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MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251125105619.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
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200827t20192019my a|||f |||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0008821(Local) |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
QP105 .N37 2019 r Thesis |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Nasrul Hadi Johari, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Haemodynamics analysis of carotid artery stenosis and carotid artery stenting / |
| Statement of responsibility, etc. |
Nasrul Hadi Johari |
| 264 1# - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
London : |
| Name of producer, publisher, distributor, manufacturer |
Imperial College London. |
| Date of production, publication, distribution, manufacture, or copyright notice |
2019 |
| 264 1# - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
© 2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xiii, 146 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Doctor of Philosophy) -- Imperial College London -- 2019 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Carotid stenosis is a local narrowing of the carotid artery, and is usually found in the internal carotid artery. The presence of a high-degree stenosis in a carotid artery may provoke transition from laminar to turbulent flow during part of the cardiac cycle. Turbulence in blood flow can influence haemodynamic parameters such as velocity profiles, shear stress and pressure, which are important in wall remodelling. Patients with severe stenosis could be treated with a minimally invasive clinical procedure, carotid artery stenting (CAS). Although CAS has been widely adopted in clinical practice, the complication of in-stent restenosis (ISR) has been reported after CAS. The incidence of ISR is influenced by stent characteristics and vessel geometry, and correlates strongly with regions of neointimal hyperplasia (NH). Therefore, the main purpose of this study is to provide more insights into the haemodynamics in stenosed carotid artery and in post-CAS geometries via computational simulation. The first part of the thesis presents a computational study on flow features in a stenotic carotid artery bifurcation using two computational approaches, large eddy simulation (LES) and Reynolds-averaged Navier-Stokes (RANS) incorporating the Shear Stress Transport model with the γ-Reθ transition (SST-Tran) models. The computed flow patterns are compared with those measured with particle image velocimetry (PIV). The results show that both SST-Tran and LES can predict the PIV results reasonably well, but LES is more accurate especially at locations distal to the stenosis where flow is highly disturbed. The second part of the thesis is to determine how stent strut design may influence the development of ISR at the carotid artery bifurcation following CAS. Key parameters that can be indicative of ISR are obtained for different stent designs and compared; these include low and oscillating wall shear stress (WSS),high residence time, and wall stress. A computationally efficient methodology is employed to reproduce stent strut geometry. This method facilitates the accurate reconstruction of actual stent geometry and details of strut configuration and its inclusion in the fluid domain. Computational simulations for flow patterns and low-density lipoprotein (LDL) transport are carried out in order to investigate spatial and temporal variations of WSS and LDL accumulation in the stented carotid geometries. Furthermore, finite element (FE) analysis is performed to evaluate the wall stress distribution with different stent designs. The results reveal that the closed-cell stent design is more likely to create atheroprone and procoagulant flow conditions, causing larger area to be exposed to low wall shear stress (WSS), elevated oscillatory shear index, as well as to induce higher wall stress compared to the open-cell stent design. This study also demonstrates the suitability of SST-Tran and LES models in capturing the presence of complex flow patterns in post-stenotic region. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Hemodynamics |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |