MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04354nam a22003497a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20251125110039.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
|---|
| fixed length control field |
a||||fr|||| 001 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
|---|
| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
220421t20212021my a|||fram|| 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
THE0009319(Local) |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
KK .R36 2021 r Thesis |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ramprasath Ramakrishnan, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
3d hierarchical nanofiber scaffolds by needless electrospinning for drug delivery applications / |
| Statement of responsibility, etc. |
Ramprasath Ramakrishnan |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Kuantan, Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMP, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2021 |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
© 2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xvii, 122 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
30 cm. + |
| Accompanying material |
1 CD ROM |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 500 ## - GENERAL NOTE |
|---|
| General note |
College of Engineering |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2021 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Nanofiber scaffolds plays a significant role in targeted drug delivery applications. Traditionally the nanofibers are produced from polymer solution by applying a high voltage between the needle tip and the collector ground surface and the process is called electrospinning. However, needle-based electrospinning has a major drawback on mass production and to maintain the reproducibility. This issue was addressed using needleless electrospinning in this study. However, the effect of polymer solution properties and regulated drug release by nanofiber from needleless electrospinning has not yet been completely understood, hence this is the aims of this research. In addition, the biological effect on breast cancer cell lines of the drug loaded nanofiber is also studied. Organic biopolymer such as poly ethylene oxide (PEO), poly (lactic acid) (PLA) and poly caprolactone (PCL) are used in this work to produce the nanofibers scaffold along with the model drug of bovine serum albumin protein (BSA) and titanocene dichloride (Cp2TiCl2) for drug delivery applications. Two types of scaffolds were produced, which is a monolayer PCL nanofiber with drug loaded directly in the polymer solution to study the release of the drug. The second method was multilayer where PCL nanofiber was used as drug containing scaffold with PLA nanofiber acting as a barrier for drug release. The diffusion mechanism was found from the controlled release kinetic study. The study on solution properties shows that PEO solution has a shear thinning property and that a non-conductive PEO polymers can be electrospun to produce a nanofiber with electrolyte addiction. The surface morphology study indicates the produced fibers are less than 200 nm in diameter and amorphous in nature. The results of control release study showed a diffusion release mechanism of drug from a mono layer nanofiber within 48 hrs, while a very small release obtained from the multilayer fiber for similar time period. The two model drugs, i.e. bovine serum albumin protein (BSA) and titanocene dichloride (Cp2TiCl2) was found to be viable in the nanofiber after undergoing a high voltage process. The TEM and SAED pattern shows the materials is amorphous in nature. The FTIR and DSC thermal properties of the nanofibers shows no changes in chemical or thermal properties when compared with previously reported conventional electrospun nanofiber. The biological properties of the PCL-Titanocene dichloride monolayer and multilayer nanofibers were evaluated through the in-vitro cytotoxicity studies using MDA-MB-231 cell lines (Human Breast Adenocarcinoma) and L929 fibroblast cell lines. It was found that the nanofiber doped with Cp2TiCl2 effectively reduce the MDA-MB-231 viability from 93.68% to 57.04%. Flow cytometric analysis confirmed a distinct inhibition of cells at Go/G1 phase in groups treated with nanofiber doped with Cp2TiCl2 with 10.74% apoptotic after 24 h compared to the control cells. This work may serve as a useful guide in understanding the parameters useful for industrial scaleup in developing a nanofiber-based targeted drug delivery scaffold for broader commercial application |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
College of Engineering |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Theses |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Restricted Collection |