Optical uric acid detection system in the ultraviolet (uv) region for gout diagnosis application / (Record no. 97078)

MARC details
000 -LEADER
fixed length control field 04355ntm a2200361 i 4500
003 - CONTROL NUMBER IDENTIFIER
control field MY-KuUP
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251125110039.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
fixed length control field t||||fr|||| 000 0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220422s2021 my a|||frm||| 000 0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number THE0009341(Local)
Qualifying information hardback
040 ## - CATALOGING SOURCE
Original cataloging agency UMP
Language of cataloging eng
Transcribing agency UMP
Description conventions rda
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) FTKEE .M39 2021 r Thesis
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Nor Mazlee Norazmi,
Relator term author.
245 10 - TITLE STATEMENT
Title Optical uric acid detection system in the ultraviolet (uv) region for gout diagnosis application /
Statement of responsibility, etc. Nor Mazlee Norazmi
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Kuantan, Pahang :
Name of producer, publisher, distributor, manufacturer UMP,
Date of production, publication, distribution, manufacture, or copyright notice 2021
264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice © 2021
300 ## - PHYSICAL DESCRIPTION
Extent xviii, 177 pages :
Other physical details illustrations (some color) ;
Dimensions 30 cm. +
Accompanying material 1 CD ROM
336 ## - CONTENT TYPE
Content type term text
Source rdacontent
336 ## - CONTENT TYPE
Content type term text
Source rdacontent
337 ## - MEDIA TYPE
Media type term unmediated
Source rdamedia
337 ## - MEDIA TYPE
Media type term computer
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term volume
Source rdacarrier
338 ## - CARRIER TYPE
Carrier type term computer disc
Source rdacarrier
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
500 ## - GENERAL NOTE
General note Faculty of Electrical & Electronics Engineering
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2021
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc. note Includes bibliographical references
520 3# - SUMMARY, ETC.
Summary, etc. This thesis describes an optical fibre sensor for the detection of uric acid (U.A) molecules and measurement of its concentration in the Ultraviolet (UV) wavelength region. Based on the medical studies, the concentration of uric acid which exceeds the normal rate ( > 7mg/dL for men and > 6mg/dL for women) in the human body can lead to Hyperuricemia and form numerous crystallites in the human joints. This disease is called Gout which is a common disease nowadays. It may cause swelling, intense pain and joint inflammation to the patient especially during intense activities. Various methods are carried out to measure uric acid concentration in the human body. Current practices have drawbacks that consume a lot of time to give results. Certain techniques are based on the consumption of another element for measuring the uric acid concentration in the sample. In certain experiments, a uric acid sample is mixed with a particular substance which can give effects on the properties and concentration of uric acid. In this research, an open-path optical sensor was developed to identify the optimal wavelength of uric acid molecule and measure its concentration in the UV region with a fast detection time, 3s. The developed optical sensor was also tested through the openpath technique to measure a few set of uric acid concentrations. The uric acid sample were prepared with different concentrations; 0.2mg/ml, 0.4mg/ml, 0.6mg/ml, 0.8mg/ml and 1.0mg/ml. The working principle is based on spectroscopy study. The absorption cross-section was calculated using Beer’s Lambert Law formula to indicate the absorption curve peak of the uric acid molecule due to its molecular structure. Spectrometer calibration was done using the Mercury HG-1 lamp to ensure that the optical sensor gives results with less errors. The experimental setup consists of a deuterium light source, spectrometer, cuvette holder, cuvette, optical fibre cables and computer to display results. The firmware of the sensor was developed using LabVIEW to make the sensor work in real-time. Spectrasuite does not have this advantage since the data has to be manually collected for analysis. In the experiment, the optical sensor was successfully optimized. The noise reduction was done using the average method. The sensor is able to measure the uric acid concentration of the five samples at the particular UV absorption curve peak, 294.46nm with a low noise signal. The cross-sensitivity issue occurs between uric acid and urea since both of these molecule absorb UV light at the same wavelength. The absorption curve line of urea was successfully deducted using the ratio technique. Thus, the optical sensor is able to only measure uric acid concentration. The absorption of carbon dioxide and oxygen can be ignored due to very low absorption in the UV region. This is a good potential that the optical sensor can identify the optimum wavelength of a uric acid molecule and measure the concentration in a short time. It is 60 times faster than the existing technique.
610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Electrical & Electronics Engineering Technology
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Universities and colleges
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Theses
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Library of Congress Classification
Koha item type Restricted Collection
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Use restrictions Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Barcode Date last seen Copy number Price effective from Koha item type
  Not lost Library of Congress Classification   Restricted access   Reference UMPLIB PEKAN UMPLIB PEKAN Reference 22/04/2022   FTKEE .M39 2021 r Thesis T000001838 09/06/2022 1 22/04/2022 Restricted Collection
  Not lost Library of Congress Classification   Restricted access   Reference UMPLIB PEKAN UMPLIB PEKAN Reference 22/04/2022   CD13085 T000001839 22/04/2022 1 22/04/2022 Restricted Collection

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