Effects of encapsulation and boundary proximity on the dynamical response of microbubbles in ultrasonic fields / (Record no. 99513)

MARC details
000 -LEADER
fixed length control field 05104ntm a2200373 i 4500
003 - CONTROL NUMBER IDENTIFIER
control field MY-KuUP
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20251125110738.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
fixed length control field t||||fr|||| 000 0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field ta
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 230516t20232023my a|||fr|||| 000 0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number THE0009624 (Local)
Qualifying information Hardback
040 ## - CATALOGING SOURCE
Original cataloging agency UMP
Language of cataloging eng
Transcribing agency UMP
Description conventions rda
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) FTKMA .N35 2023 r Thesis
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Najihah Mohd Ali,
Relator term author.
245 10 - TITLE STATEMENT
Title Effects of encapsulation and boundary proximity on the dynamical response of microbubbles in ultrasonic fields /
Statement of responsibility, etc. Najihah Binti Mohd Ali
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Kuantan, Pahang :
Name of producer, publisher, distributor, manufacturer UMP,
Date of production, publication, distribution, manufacture, or copyright notice 2023
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice © 2023
300 ## - PHYSICAL DESCRIPTION
Extent xiv, 121 pages :
Other physical details illustrations (some color) ;
Dimensions 30 cm. +
Accompanying material 1 CD-ROM
336 ## - CONTENT TYPE
Source rdacontent
Content type term text
336 ## - CONTENT TYPE
Source rdacontent
Content type term text
337 ## - MEDIA TYPE
Source rdamedia
Media type term unmediated
337 ## - MEDIA TYPE
Source rdamedia
Media type term computer
338 ## - CARRIER TYPE
Source rdacarrier
Carrier type term volume
338 ## - CARRIER TYPE
Source rdacarrier
Carrier type term computer disc
347 ## - DIGITAL FILE CHARACTERISTICS
Source rda
File type text file
Encoding format PDF
500 ## - GENERAL NOTE
General note Faculty of Mechanical and Automotive Engineering Technology
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Master of Science) -- Universiti Malaysia Pahang – 2023
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc. note Includes bibliographical references
520 3# - SUMMARY, ETC.
Summary, etc. Microbubbles are currently used as ultrasound contrast agents, but they also have the potential to be used for diagnostic imaging and therapeutic delivery such as drug delivery, gene therapy, molecular imaging, anti-cancer therapy, and atherosclerotic therapy. However, the transition from using microbubbles as ultrasound contrast agents to applications in the biomedical field requires more in-depth understanding. Nevertheless, experimental studies in recent years have shown that the boundary has a substantial effect on microbubble oscillation. In reality, the possible clinical applications of microbubbles necessitate that they be kept close to the vessel wall at all times, effectively near a boundary. Since the interaction between ultrasound and microbubble oscillation is nonlinear, any changes in parameters or conditions can cause the bubble dynamics to change. Moreover, of particular importance is the influence of microbubble encapsulation near the boundary on overall dynamic behaviour as the bubble is stabilised. However, many bubble studies have not considered shell encapsulation. In order to effectively manipulate and monitor microbubble oscillation, it is necessary to understand how the boundary and encapsulating shell affect microbubble vibration. Therefore, this research aims to determine the effects of boundary proximity on the gas microbubble dynamic response in an ultrasonic field. The second objective of this research is to investigate the effects of shell-encapsulated microbubbles and neighbouring microbubbles near the boundary in an ultrasonic field. To achieve the research objectives, theoretical models were modified. The equations of the models were modified to elucidate the influence of the boundary on the oscillating microbubble, and the influence of shell-encapsulated microbubbles and neighbouring microbubbles. These models were subjected to a set of ultrasound parameters observed in clinical studies. The dynamics of the microbubble near a boundary in an ultrasonic field was determined by numerically solving the governing equations for microbubble oscillation. The distances between the microbubble were varied along with driving frequency. The microbubble oscillation was studied in terms of time response, bifurcation diagrams, and maximum radial expansion. The chaos theory of dynamical microbubble is employed to visualise the parameter dependence of the bubble dynamics through bifurcation diagrams. This is because, dynamical response of a microbubble subjected to ultrasound is a complex chaotic dynamic system. The results showed that the microbubble oscillation became increasingly irregular as the driving pressure amplitude was increased, while the maximum amplitude of oscillation was found to decrease with increasing ultrasound frequency. Also, the boundary was found to suppress the bubble oscillations, causing an increase in the orderly periodic solutions, and reducing the maximum radial expansion. The increase in distance between the boundary and the encapsulated bubble also increased the oscillation amplitude. When the value of the pressure amplitude increased, the single bubble was more likely to exhibit chaotic behaviour. Besides, the maximum radius also increased as the inter-wall-bubble distance was gradually increased. Meanwhile, with higher driving frequency, the maximum radial expansion decreased and suppressed chaotic behaviour. The results also suggest that the presence of the boundary shifted the transition from orderly to chaotic, with it occurring at a lower control parameter value of the incident ultrasound. In addition, the combined influence of boundary proximity and ultrasound parameters caused a shift in the fundamental frequency of the bubbles.
610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Mechanical and Automotive Engineering Technology
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Universities and colleges
General subdivision Dissertations
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Theses
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Library of Congress Classification
Koha item type Restricted Collection
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Date acquired Total checkouts Full call number Barcode Date last seen Copy number Price effective from Koha item type
  Not lost Library of Congress Classification   Not for loan Reference UMPLIB PEKAN UMPLIB PEKAN 16/05/2023   FTKMA .N35 2023 r Thesis T000002346 16/05/2023 1 16/05/2023 Restricted Collection
  Not lost Library of Congress Classification     Reference UMPLIB PEKAN UMPLIB PEKAN 16/05/2023   CD 13339 T000002347 16/05/2023 1 16/05/2023 Restricted Collection

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