MARC details
| 000 -LEADER |
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04817nam a2200373 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MY-KuUP |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20251125110740.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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a||||fr|||| 000 0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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230612t20232023my a|||fr|||| 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
THE0009662 (Local) |
| Qualifying information |
Hardback |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UMP |
| Language of cataloging |
eng |
| Transcribing agency |
UMP |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
FTKKP .Y44 2023 r Thesis |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Lim Yee Peng, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Characterization of encapsulated bioactive compound extracted from phaleria macrocarpa by using ultrasonic assisted extraction / |
| Statement of responsibility, etc. |
Lim Yee Peng |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Pahang : |
| Name of producer, publisher, distributor, manufacturer |
UMP, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2023 |
| 264 #3 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
©2023 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xxiii, 234 pages : |
| Other physical details |
Illustration ; |
| Dimensions |
30 cm.+ |
| Accompanying material |
1 CD-ROM |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
computer |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
computer disc |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
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| Source |
rda |
| File type |
text file |
| Encoding format |
PDF |
| 500 ## - GENERAL NOTE |
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| General note |
Faculty of Chemical and Process Engineering Technology |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2022 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Phaleria macrocarpa is an evergreen plant with various pharmaceutical properties. Its marker compound, mangiferin was well known of its anticancer property. However, neomangiferin and isomangiferin were first time reported in P. macrocarpa extraction. Although maceration (ME) was intensively used to extract the bioactive polyphenols, ME requires lengthy extraction time and produces low bioactive compound yield. Thus, modern extraction techniques, sonication bath and microwave assisted extraction (MAE) were also applied to reduce the extraction time and increase the extraction efficiency. Moreover, the different level of auxiliary energies by each extraction technique affects the bioactive compound yield. Therefore, the first objective of this work is to investigate the effect of auxiliary energy on polyphenol extraction from P. macrocarpa fruits using Principal Component Analysis (PCA). The use of high temperature during extraction and spray drying could degrade the P. macrocarpa polyphenols. Thus, the thermal stability and degradation mechanism of P. macrocarpa polyphenols is needed to be understood and hence this is another objective of this research. The microencapsulation of P. macrocarpa extract using different wall material is required to protect P. macrocarpa polyphenols from degradation during spray drying and affects the release in simulated gastro intestine condition. Thus, the last objective of this research is to microencapsulate P. macrocarpa and investigate its release profile in the digestive tract. Optimum extraction conditions of ME (80 °C for 1 hour), ultrasonic assisted extraction, UAE (60 % for 5 min) and MAE (5 W for 7 min) had auxiliary energies of 0.05, 1.31 and 1.00 W/ml. The difference in composition among extraction techniques was evaluated by principal component analysis (PCA). Heat treatment of P. macrocarpa polyphenols as standards and in extract were carried out at 120 and 150 °C for 180 min to evaluate reaction rate constant (k), half-life (t1/2), activation energy (Ea), activation enthalpy (ΔH), Gibbs free energy (ΔG) and activation entropy (ΔS). Microencapsulation via spray drying was carried out with three different formulations, 10 wt.% of maltodextrin (MD), whey protein isolate (WPI) and MD:WPI (9:1). The release rate of polyphenols was evaluated by five different mathematical models, first order, Higuchi, Hixon-Crowell, Baker and Lonsdale, Korsmeyer-Peppas. The highest neomangiferin (1.71 mg/g DW) and mangiferin (28.58 mg/g DW) yield were obtained at the highest auxiliary energy using UAE. PCA provide 67% of variability, where UAE and MAE were distinguished from ME, attributed to mangiferin, isomangiferin, mahkoside A, dihydroxy methoxyxanthone-O-glucoside and 5,6,7,8-tetrahydronorbellidifodin derivative of mangiferin. Neomangiferin and mangiferin obeyed second and first order kinetics respectively and rate constants of 0.0014 mol-1 min -1 and 0.0019 min -1 respectively at 120 °C. The negative ΔS (-358.78 to -19.72 J/mol.K) and positive ΔG (123.02 – 134.14 kJ/mol) values implied the degradation of polyphenols was non spontaneous. Maltodextrin encapsulated powder retained the highest neomangiferin (97.14 %) mangiferin (96.25%) and isomangiferin (99.19%) yields. The release of polyphenols from MD obeyed Korsmeyer-Peppas model with Fickian diffusion. In short, the extraction conditions, thermal stability and microencapsulation of the study can be a vital guidance for supplement industry. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
Faculty of Chemical and Process Engineering Technology |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Universities and colleges |
| General subdivision |
Dissertations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Thesis |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Thesis |