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Evaluation of the effects of kyllinga nemoralis cream in rat model of skin-induced allergy / Chao Miao Sheng

By:

Chao Miao Sheng [author.]

Material type: Text

text

Media type:

unmediated

Carrier type:

volume

ISBN:

THE0010289 (Local)

Subject(s):

Dissertation note: Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: Skin allergies, including atopic dermatitis (AD), are chronic inflammatory conditions that significantly affect quality of life and pose treatment challenges. This study investigates the therapeutic potential of Kyllinga nemoralis extract, known for its anti-inflammatory properties, in a rat model of skin-induced allergy. AD-like lesions were induced using 2,4-dinitrochlorobenzene (DNCB), followed by treatment with K. nemoralis cream at 5% and 10% concentrations. Key metrics, including skin scaling scores, body weight, food intake, and organ weights (liver and kidney), were evaluated. The 5 % cream significantly reduced skin scaling scores from 2.80 ± 0.37 to 1.00 ± 0.00 after 7 days, outperforming the 10% formulation. Liver weights remained unaffected, while untreated lesions showed significantly different in kidney weight, suggesting potential adverse effects of untreated AD. The results, comparable to 1% hydrocortisone cream, indicate K. nemoralis as a promising natural treatment for inflammatory skin conditions. Further studies, including human trials and pharmacokinetic analyses, are recommended to confirm its clinical applicability

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Title notes ( 4 )

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Restricted Collection	UMPLIB GAMBANG	FIST .C43 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000003668

Faculty of Industrial Sciences and Technology

Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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Skin allergies, including atopic dermatitis (AD), are chronic inflammatory conditions that significantly affect quality of life and pose treatment challenges. This study investigates the therapeutic potential of Kyllinga nemoralis extract, known for its anti-inflammatory properties, in a rat model of skin-induced allergy. AD-like lesions were induced using 2,4-dinitrochlorobenzene (DNCB), followed by treatment with K. nemoralis cream at 5% and 10% concentrations. Key metrics, including skin scaling scores, body weight, food intake, and organ weights (liver and kidney), were evaluated. The 5 % cream significantly reduced skin scaling scores from 2.80 ± 0.37 to 1.00 ± 0.00 after 7 days, outperforming the 10% formulation. Liver weights remained unaffected, while untreated lesions showed significantly different in kidney weight, suggesting potential adverse effects of untreated AD. The results, comparable to 1% hydrocortisone cream, indicate K. nemoralis as a promising natural treatment for inflammatory skin conditions. Further studies, including human trials and pharmacokinetic analyses, are recommended to confirm its clinical applicability