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Evaluation of antibacterial properties and topical application of kyllinga nemoralis extract in allergic-induced skin lesion in rats / Lim Kok Ling

By:

Lim, Kok Ling [author.]

Material type: Object

text

Media type:

unmediated

Carrier type:

volume

ISBN:

THE0010305 (Local)

Subject(s):

Dissertation note: Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: Traditional medicine as a vital source of healthcare globally, with plants like Kyllinga nemoralis offering significant therapeutic potential. Despite its extensive ethnomedicinal use, the antibacterial efficacy of K. nemoralis, particularly in managing skin allergies complicated by bacterial infections, has not been extensively studied. This study aimed to investigate the antibacterial activity of K. nemoralis and its therapeutic effects in an allergy-induced rat model. To achieve this goal, K. nemoralis methanolic extract was prepared using Soxhlet apparatus, followed by phytochemical analysis via Gas Chromatography-Mass Spectrometry (GC-MS). Antibacterial activity of K. nemoralis was assessed through agar disc diffusion and minimum inhibitory concentration (MIC) assays against Bacillus subtilis and Escherichia coli. A 10% K. nemoralis extract cream was formulated and tested in an-allergy-induced dermatitis rat model, which established using 2,4-dinitrochlorobenzene (DNCB). The extract demonstrated moderate antibacterial activity, with MIC values of 1.88 mg/mL against B. subtilis and 3.75 mg/mL against E. coli. In vivo, the 10% extract cream significantly reduced dermatitis scores of the treatment group from 6.60 to 1.80, indicating its efficacy in combating bacterial infections and alleviating allergic skin conditions. These findings highlighted K. nemoralis as a natural antibacterial agent and a therapeutic option for managing skin infections and allergies

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Title notes ( 4 )

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Restricted Collection	UMPLIB GAMBANG	FIST .K65 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000003683

Faculty of Industrial Sciences and Technology

Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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Traditional medicine as a vital source of healthcare globally, with plants like Kyllinga nemoralis offering significant therapeutic potential. Despite its extensive ethnomedicinal use, the antibacterial efficacy of K. nemoralis, particularly in managing skin allergies complicated by bacterial infections, has not been extensively studied. This study aimed to investigate the antibacterial activity of K. nemoralis and its therapeutic effects in an allergy-induced rat model. To achieve this goal, K. nemoralis methanolic extract was prepared using Soxhlet apparatus, followed by phytochemical analysis via Gas Chromatography-Mass Spectrometry (GC-MS). Antibacterial activity of K. nemoralis was assessed through agar disc diffusion and minimum inhibitory concentration (MIC) assays against Bacillus subtilis and Escherichia coli. A 10% K. nemoralis extract cream was formulated and tested in an-allergy-induced dermatitis rat model, which established using 2,4-dinitrochlorobenzene (DNCB). The extract demonstrated moderate antibacterial activity, with MIC values of 1.88 mg/mL against B. subtilis and 3.75 mg/mL against E. coli. In vivo, the 10% extract cream significantly reduced dermatitis scores of the treatment group from 6.60 to 1.80, indicating its efficacy in combating bacterial infections and alleviating allergic skin conditions. These findings highlighted K. nemoralis as a natural antibacterial agent and a therapeutic option for managing skin infections and allergies