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Nanofibers fabrication of trigonella foenum graecum extract loaded poly lactic ACID and gelatin with nano cellulose as carrier for antimicrobial applications / Kuan Yeh Xi

By:

Kuan, Yeh Xi, , [author.]

Material type: Text

text

Media type:

unmediated

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volume

ISBN:

THE0010731 (Local)

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Dissertation note: Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: The global challenge of antibiotic resistance demands innovative solutions, particularly in the development of sustainable and biocompatible antimicrobial materials. This study aimed to extract and characterize the antimicrobial properties of Fenugreek, and to fabricate and characterize Fen/PLA/Gel/NCC nanofibers. Fenugreek extract was obtained through maceration and characterized using UV-Vis spectroscopy, confirming the presence of antimicrobial compounds such as phenolic acids, flavonoids, and trigonelline. Nanofibers were fabricated using needleless electrospinning, with the process parameter of height between wire electrode and aluminium foil optimized to produce bead-free nanofibers. Advanced characterization techniques, including SEM, FTIR, TGA, and XRD, were utilized to analyze the morphology, thermal stability, and crystalline structure of the nanofibers. Results demonstrated that the optimized Fen/PLA/Gel/NCC nanofibers exhibited enhanced antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as evidenced by significant inhibition zones. The incorporation of NCC improved the thermal stability of the nanofibers, while the combination of PLA, Gelatin, and Fenugreek extract contributed to their biocompatibility and biodegradability. The best-performing nanofiber was identified with the ratio of Fen/PLA/Gel/NCC at 10:10:0.2:0.1 % w/v, providing the optimal balance of antimicrobial activity, structural integrity, and thermal stability. Recommendations include further optimization of fabrication parameters, comprehensive antimicrobial testing, drug efficiency studies, and isolation of specific bioactive compounds from Fenugreek extract to maximize the nanofiber’s potential. This study underscores the feasibility of Fen/PLA/Gel/NCC nanofibers as an effective solution for antimicrobial applications in healthcare and material science.

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Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	FTKKP .Y44 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000004324

Faculty of Chemical and Process Engineering Technology

Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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The global challenge of antibiotic resistance demands innovative solutions, particularly in the development of sustainable and biocompatible antimicrobial materials. This study aimed to extract and characterize the antimicrobial properties of Fenugreek, and to fabricate and characterize Fen/PLA/Gel/NCC nanofibers. Fenugreek extract was obtained through maceration and characterized using UV-Vis spectroscopy, confirming the presence of antimicrobial compounds such as phenolic acids, flavonoids, and trigonelline. Nanofibers were fabricated using needleless electrospinning, with the process parameter of height between wire electrode and aluminium foil optimized to produce bead-free nanofibers. Advanced characterization techniques, including SEM, FTIR, TGA, and XRD, were utilized to analyze the morphology, thermal stability, and crystalline structure of the nanofibers. Results demonstrated that the optimized Fen/PLA/Gel/NCC nanofibers exhibited enhanced antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as evidenced by significant inhibition zones. The incorporation of NCC improved the thermal stability of the nanofibers, while the combination of PLA, Gelatin, and Fenugreek extract contributed to their biocompatibility and biodegradability. The best-performing nanofiber was identified with the ratio of Fen/PLA/Gel/NCC at 10:10:0.2:0.1 % w/v, providing the optimal balance of antimicrobial activity, structural integrity, and thermal stability. Recommendations include further optimization of fabrication parameters, comprehensive antimicrobial testing, drug efficiency studies, and isolation of specific bioactive compounds from Fenugreek extract to maximize the nanofiber’s potential. This study underscores the feasibility of Fen/PLA/Gel/NCC nanofibers as an effective solution for antimicrobial applications in healthcare and material science.