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Assessment of surface-engineered hyaluronic acid-nano-zeolitic imidazolate framework-8 in the embryo zebrafish model / Nor Afifah Binti Mohd Nordin

By:

Nor Afifah Binti Mohd Nordin, , [author.]

Material type: Text

text

Media type:

unmediated

Carrier type:

volume

ISBN:

THE0010740 (Local)

Subject(s):

Online resources:

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Dissertation note: Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: Colon cancer is potentially life-threatening if not detected early. Colon cancer is treatable, typically through surgery which often combines with chemotherapy or radiation therapy yet has many limitations. Hence, to address the limitations of chemotherapy medications, it is significantly crucial for the development of targeted nanosystems that can be highly selective towards cancer cells while enhancing the efficacy and safety of the drug delivery system. In previous research, a zeolitic imidazole framework-8 (ZIF-8), An emerging nanoparticle was suppressed to surface engineered using Hyaluronic Acid (HA) acting as targeting agent for these studies through one-pot solvothermal reaction. The unique characteristics of pristine nano zeolitic imidazole framework-8 (nZIF-8) and Hyaluronic Acid-engineered nano zeolitic imidazole framework-8 (HA@nZIF-8) were assess and execute in of surface area, particle size, newly formed functional groups and surface structure. When modified with the hyaluronic acid, the nano zeolitic imidazole framework-8 likelihood to improve the optimal chemotherapeutic dosage for colon cancer while minimizing unnecessary toxicity towards healthy cell and facilitate higher selective targeting system.

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Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	FTKKP .A354 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000004334

Faculty of Chemical and Process Engineering Technology

Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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Colon cancer is potentially life-threatening if not detected early. Colon cancer is treatable, typically through surgery which often combines with chemotherapy or radiation therapy yet has many limitations. Hence, to address the limitations of chemotherapy medications, it is significantly crucial for the development of targeted nanosystems that can be highly selective towards cancer cells while enhancing the efficacy and safety of the drug delivery system. In previous research, a zeolitic imidazole framework-8 (ZIF-8), An emerging nanoparticle was suppressed to surface engineered using Hyaluronic Acid (HA) acting as targeting agent for these studies through one-pot solvothermal reaction. The unique characteristics of pristine nano zeolitic imidazole framework-8 (nZIF-8) and Hyaluronic Acid-engineered nano zeolitic imidazole framework-8 (HA@nZIF-8) were assess and execute in of surface area, particle size, newly formed functional groups and surface structure. When modified with the hyaluronic acid, the nano zeolitic imidazole framework-8 likelihood to improve the optimal chemotherapeutic dosage for colon cancer while minimizing unnecessary toxicity towards healthy cell and facilitate higher selective targeting system.