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Fabrication and characterization of drug-loaded pla-starch nanofibers via electrospinning for biomedical application / Ainaa Alyaana Binti Omar

By:

Ainaa Alyaana Binti Omar, , [author.]

Material type: Text

text

Media type:

unmediated

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volume

ISBN:

THE0010768 (Local)

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Dissertation note: Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceutical) with Hons.) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: The development of biodegradable nanofibers has drawn a lot of interest in biomedical applications because of its potential for tissue engineering as well as controlled drugs delivery. The electrospinning technique was employed in this work to fabricate and characterise polylactic acid (PLA)-starch-based nanofibers. The study investigates how fibre structure, degradation behaviour, and structural integrity are affected by varying starch concentrations. The best qualities, such as consistent fibre development, less bead-like formations, and appropriate degradation characteristics, were demonstrated by nanofibers with 0.16% w/v starch among all the investigated formulations. The successful incorporation of starch into the PLA matrix was verified by Fourier-Transform Infrared Spectroscopy (FTIR), while better fibre shape was established by Scanning Electron Microscopy (SEM) examination. Tests of swelling and weight loss showed that the modified formulation preserved controlled degradation, indicating that it is an appropriate choice for application in biomedical applications. The results indicate that PLA-starch nanofibers, especially at 0.16% w/v starch, have a lot of potential for application in wound healing and drug delivery systems. To improve nanofiber performance, more optimisations are recommended, such as long-term degradation study and improvements to the electrospinning parameters.

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Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Restricted Collection	UMPLIB GAMBANG	FTKKP .A366 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000004362

Faculty of Chemical and Process Engineering Technology

Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceutical) with Hons.) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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The development of biodegradable nanofibers has drawn a lot of interest in biomedical applications because of its potential for tissue engineering as well as controlled drugs delivery. The electrospinning technique was employed in this work to fabricate and characterise polylactic acid (PLA)-starch-based nanofibers. The study investigates how fibre structure, degradation behaviour, and structural integrity are affected by varying starch concentrations. The best qualities, such as consistent fibre development, less bead-like formations, and appropriate degradation characteristics, were demonstrated by nanofibers with 0.16% w/v starch among all the investigated formulations. The successful incorporation of starch into the PLA matrix was verified by Fourier-Transform Infrared Spectroscopy (FTIR), while better fibre shape was established by Scanning Electron Microscopy (SEM) examination. Tests of swelling and weight loss showed that the modified formulation preserved controlled degradation, indicating that it is an appropriate choice for application in biomedical applications. The results indicate that PLA-starch nanofibers, especially at 0.16% w/v starch, have a lot of potential for application in wound healing and drug delivery systems. To improve nanofiber performance, more optimisations are recommended, such as long-term degradation study and improvements to the electrospinning parameters.