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Biodegradable electrospun fibers for drug delivery application / Azila Azura Juma'at

By:

Azila Azura Juma'at

Material type: Text

TextPublication details: Kuantan, Pahang : UMP, 2010Description: xiv, 60 p. : ill. (some col.) ; 30 cm. + 1 CD-ROMISBN:

THE0002456(Local)

Subject(s):

Dissertation note: Project paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2010 Abstract: The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning (electro+spinning). Controlled drug delivery systems have gained much attention in the last few decades. This is due to the many advantages compared with the conventional dosage forms such as improving therapeutic efficacy and reducing toxicity by delivering them at a controlled rate to the specific site. The objective of this research is to study the drug release behavior from the electrospun scaffolds and its antimicrobial effects on microbacteria culture. Non-steroidal anti-inflammatory drug (NSAID) was embedded in two types of polymer; polylactide acid (PLLA) and polycaprolactone(PCL) with the parameters of drug concentration; 5% of indomethacin concentration and no indomethacin concentration (control), and types of microbacteria used; E.coli sp., B.cereus sp., and M.luteus sp. All the microbacterial cultures were incubated for an overnight at 37°C. Results showed throughout the study, the absorbance for polymer with no drug concentration is higher than polymer with 5% of drug concentration as there is no drugs diffuse from the polymer to inhibit the microbial growth. The growth of microbacterial can be visualized directly from the plate to assess the viability of indomethacin release. In this study, it is clear that these PLLA and PCL-with indomethacin based electrospun scaffolds hold a future potential in drug delivery system.

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Holdings ( 2 )
Title notes ( 3 )

Holdings
Item type	Current library	Call number	Copy number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	TA418.9.F5 A95 2010 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000060881
Final Year Report	UMPLIB GAMBANG	CD 5606 \| TA418.9.F5 A95 2010 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000060882

Project paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2010

Bibliography: p. 54-55

The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning (electro+spinning). Controlled drug delivery systems have gained much attention in the last few decades. This is due to the many advantages compared with the conventional dosage forms such as improving therapeutic efficacy and reducing toxicity by delivering them at a controlled rate to the specific site. The objective of this research is to study the drug release behavior from the electrospun scaffolds and its antimicrobial effects on microbacteria culture. Non-steroidal anti-inflammatory drug (NSAID) was embedded in two types of polymer; polylactide acid (PLLA) and polycaprolactone(PCL) with the parameters of drug concentration; 5% of indomethacin concentration and no indomethacin concentration (control), and types of microbacteria used; E.coli sp., B.cereus sp., and M.luteus sp. All the microbacterial cultures were incubated for an overnight at 37°C. Results showed throughout the study, the absorbance for polymer with no drug concentration is higher than polymer with 5% of drug concentration as there is no drugs diffuse from the polymer to inhibit the microbial growth. The growth of microbacterial can be visualized directly from the plate to assess the viability of indomethacin release. In this study, it is clear that these PLLA and PCL-with indomethacin based electrospun scaffolds hold a future potential in drug delivery system.