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Molecular dynamics simulation of ibuprofen crystal polymorph / Mohammad Safuan Mat Noor

By:

Mohammad Safuan Mat Noor

Material type: Text

TextPublication details: Kuantan, Pahang : UMP, 2012Description: xix, 82 p. : ill. ; 30 cm. + 1 CD-ROMISBN:

THE0002196(Local)

Subject(s):

Dissertation note: Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2012 Abstract: Ibuprofen (iso-butyl-propanolic acid) is one of the Active Pharmaceutical Ingredients (API) that uses to treat a symptom of rheumatism, arthritis, fever, as an analgesic (pain reliever). This study aims to identify which solvents should affect the polymorph of ibuprofen begins from the crystallization solution. The Molecular Dynamics Simulation and Fourier transform infrared (FTIR) is used to recognize which molecules that form hydrogen bond in the ibuprofen crystal polymorph. The study analysis has shown that the higher hydrogen bond between the atoms will contribute to the ibuprofen crystal polymorph. As the conclusion, only the selected atoms will contribute in the formation of desired crystal polymorph of ibuprofen.

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Holdings ( 2 )
Title notes ( 3 )

Holdings
Item type	Current library	Call number	Copy number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	QD951 .S24 2012 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000074783
Final Year Report	UMPLIB GAMBANG	CD 7091 \| QD951 .S24 2012 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000074784

Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2012

Bibliography : p. 71-74

Ibuprofen (iso-butyl-propanolic acid) is one of the Active Pharmaceutical Ingredients (API) that uses to treat a symptom of rheumatism, arthritis, fever, as an analgesic (pain reliever). This study aims to identify which solvents should affect the polymorph of ibuprofen begins from the crystallization solution. The Molecular Dynamics Simulation and Fourier transform infrared (FTIR) is used to recognize which molecules that form hydrogen bond in the ibuprofen crystal polymorph. The study analysis has shown that the higher hydrogen bond between the atoms will contribute to the ibuprofen crystal polymorph. As the conclusion, only the selected atoms will contribute in the formation of desired crystal polymorph of ibuprofen.