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Solid phase transformation and stability of carbamazepine-adipic acid co-crystal / Mohd Rohaizam Mohd Sidek

By:

Mohd Rohaizam Mohd Sidek

Material type: Text

TextPublication details: Kuantan, Pahang : UMP, 2012Description: xii, 69 p. : ill. (some col.) ; 30 cm. + 1 CD-ROMISBN:

THE0003894(Local)

Subject(s):

Dissertation note: Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012 Abstract: Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future.

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Holdings ( 2 )
Title notes ( 3 )

Holdings
Item type	Current library	Call number	Copy number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	TP156.C7 R64 2012 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000074941
Final Year Report	UMPLIB GAMBANG	CD 7170 \| TP156.C7 R64 2012 rs Bc. (Browse shelf(Opens below))	1	Not for loan		0000074942

Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012

Bibliography : p. 53

Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future.