Solid phase transformation of carbamazepine-succinic co-crystal / Engku Nadia Engku Mat Nasir
Material type:
TextPublication details: Kuantan, Pahang : UMP, 2014Description: xv, 37 p. : ill. ; 30 cm. + 1 CD-ROMISBN: - THE0003892(Local)
| Item type | Current library | Call number | Copy number | Status | Date due | Barcode | |
|---|---|---|---|---|---|---|---|
Final Year Report
|
UMPLIB GAMBANG | TP156.C7 N33 2014 r Bc. (Browse shelf(Opens below)) | 1 | Not for loan | 0000092131 | ||
|
Final Year Report
|
UMPLIB GAMBANG | CD 8668 | TP156.C7 N33 2014 r Bc. (Browse shelf(Opens below)) | 1 | Not for loan | 0000092132 |
Faculty of Chemical & Natural Resources Engineering
Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014
Bibliography : p. 28-31
This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed