Drug delivery in oncology : from basic research to cancer therapy / edited by Felix Kratz, Peter Senter, and Henning Steinhagen

Includes bibliographical references and index

Front Matter -- Principles of Tumor Targeting. Limits of Conventional Cancer Chemotherapy / Klaus Mross, Felix Kratz -- Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery / Peter Vaupel -- Enhanced Permeability and Retention Effect in Relation to Tumor Targeting / Hiroshi Maeda -- Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design / Jan Terje Andersen, Inger Sandlie -- Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates / Ruiwu Liu, Kai Xiao, Juntao Luo, Kit S Lam --Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far / Kenneth D Bagshawe -- Tumor Imaging. Imaging Techniques in Drug Development and Clinical Practice / John C Chang, Sanjiv S Gambhir, Jurgen K. Willmann -- Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery / Patrick D Sutphin, Efrn J. Flores, Mukesh Harisinghani -- Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT / Andreas K Buck, Florian ˜Grtner, Ambros Beer, Ken Herrmann, Sibylle Ziegler, Markus Schwaiger -- Macromolecular Drug Delivery Systems. Empowered Antibodies for Cancer Therapy / Stephen C Alley, Simone Jeger, Robert P Lyon, Django Sussman, Peter D Senter -- Mapping Accessible Vascular Targets to Penetrate Organs and Solid Tumors / Kerri A Massey, Jan E Schnitzer -- Considerations of Linker Technologies / Laurent Ducry -- Antibody-Maytansinoid Conjugates: From the Bench to the Clinic / Hans Erickson -- Calicheamicin Antibody-Drug Conjugates and Beyond / Puja Sapra, John Dijoseph, Hans-Peter Gerber -- Antibodies for the Delivery of Radionuclides / Anna M Wu -- Bispecific Antibodies and Immune Therapy Targeting / Sergej M Kiprijanov -- Design of Polymer-Drug Conjugates / Jindrich Kopecek, Pavla Kopecko`v -- Dendritic Polymers in Oncology: Facts, Features, and Applications / Mohiuddin Abdul Quadir, Marcelo Caldern, Rainer Haag -- Site-Specific Prodrug Activation and the Concept of Self-Immolation / Andr Warnecke -- Ligand-Assisted Vascular Targeting of Polymer Therapeutics / Anat Eldar-Boock, Dina Polyak, Ronit Satchi-Fainaro -- Drug Conjugates with Poly(Ethylene Glycol) / Hong Zhao, Lee M Greenberger, Ivan D Horak -- Thermo-Responsive Polymers / Drazen Raucher, Shama Moktan -- Polysaccharide-Based Drug Conjugates for Tumor Targeting / Gurusamy Saravanakumar, Jae Hyung Park, Kwangmeyung Kim, Ick Chan Kwon -- Serum Proteins as Drug Carriers of Anticancer Agents / Felix Kratz, Andreas Wunder, Bakheet Elsadek -- Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer / Coralie Deladriere, Rut Lucas, Mara J Vicent -- Clinical Experience with Drug-Polymer Conjugates / Khalid Abu Ajaj, Felix Kratz -- Nano- and Microparticulate Drug Delivery Systems. Overview on Nanocarriers as Delivery Systems / Haifa Shen, Elvin Blanco, Biana Godin, Rita E Serda, Agathe K Streiff, Mauro Ferrari -- Development of PEGylated Liposomes / I Craig Henderson -- Immunoliposomes / Vladimir P Torchilin -- Responsive Liposomes (for Solid Tumor Therapy) / Stavroula Sofou -- Nanoscale Delivery Systems for Combination Chemotherapy / Barry D Liboiron, Paul G Tardi, Troy O Harasym, Lawrence D Mayer -- Micellar Structures as Drug Delivery Systems / Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka -- Tailor-Made Hydrogels for Tumor Delivery / Sungwon Kim, Kinam Park -- pH-Triggered Micelles for Tumor Delivery / Haiqing Yin, You Han Bae -- Albumin-Drug Nanoparticles / Neil Desai -- Carbon Nanotubes / David A Scheinberg, Carlos H Villa, Freddy Escorcia, Michael R McDevitt -- Ligand-Based Drug Delivery Systems. Cell-Penetrating Peptides in Cancer Targeting / Kaido Kurrikoff, Julia Suhorut, lo Langel -- Targeting to Peptide Receptors / Andrew V Schally, Gabor Halmos -- Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy / Zeyu Xiao, Jillian Frieder, Benjamin A Teply, Omid C Farokhzad -- Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors / Iontcho R Vlahov, Paul J Kleindl, Fei You -- Drug Conjugates with Polyunsaturated Fatty Acids / Joshua Seitz, Iwao Ojima -- Special Topics. RNA Drug Delivery Approaches / Yuan Zhang, Leaf Huang -- Local Gene Delivery for Therapy of Solid Tumors / Wolfgang Walther, Peter M Schlag, Ulrike Stein -- Viral Vectors for RNA Interference Applications in Cancer Research and Therapy / Henry Fechner, Jens Kurreck -- Design of Targeted Protein Toxins / Hendrik Fuchs, Christopher Bachran -- Drug Targeting to the Central Nervous System / Gert Fricker, Anne Mahringer, Melanie Ott, Valeska Reichel -- Liver Tumor Targeting / Katrin Hochdrffer, Giuseppina Di Stefano, Hiroshi Maeda, Felix Kratz -- Photodynamic Therapy: Photosensitizer Targeting and Delivery / Pawel Mroz, Sulbha K Sharma, Timur Zhiyentayev, Ying-Ying Huang, Michael R Hamblin -- Tumor-Targeting Strategies with Anticancer Platinum Complexes / Markus Galanski, Bernhard K Keppler -- Index