Normal view MARC view ISBD view

Development and evaluation of centella asiatica powder by freeze drying : comparison of extraction methods on yield and hygroscopicity / Siti Nur Arisha Muhamad Zulkarnain

By:

Siti Nur Arisha Muhamad Zulkarnain [author.]

Material type: Text

text
text

Media type:

unmediated
computer

Carrier type:

volume
computer disc

ISBN:

THE0008620(Local)

Subject(s):

Dissertation note: Project Paper (Bachelor of Manufacturing Engineering Technology (Pharmaceutical)) -- Universiti Malaysia Pahang – 2019 Abstract: Novel techniques and the development of new methods has provided an opportunity to obtain highly purified natural bioactive compound extracts with potential for the treatment and prevention of various diseases. This research compares the percentage yield of Centella asiatica obtained through freeze drying that was aqueous-extracted earlier by conventional extraction method (decoction and infusion) and an advanced non-conventional extraction method; ultrasound-assisted extraction (UAE).The physical stability of the powder obtained was then tested by hygroscopicity test. The studies were conducted using gravimetric sorption analysis method with slight modification. Each of the powder samples was subjected to the pretreatment at 45 °C, 10% RH followed by equilibrating at 25 °C, 80% RH and individually categorized as per European Pharmacopeia. UAE generated the highest powder yield (11.65%) followed by infusion (10.48%) and decoction (10.03%). After 24 hours of hygroscopicity analysis, all three samples were found to be very hygroscopic since their respective percentage of water sorption was more than 15%. The highest percentage of water sorption was by decoction (71.31%), followed by infusion (71.28%) and lastly UAE (68.71%).

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings ( 2 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Copy number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	Reference	FTeK .A757 2019 r Bc. (Browse shelf(Opens below))	1	Final Processing		T000000105
Final Year Report	UMPLIB GAMBANG		CD12218 (Browse shelf(Opens below))	1	Not for loan		T000000106

Faculty of Engineering Technology

Project Paper (Bachelor of Manufacturing Engineering Technology (Pharmaceutical)) -- Universiti Malaysia Pahang – 2019

Includes bibliographical references

Novel techniques and the development of new methods has provided an opportunity to obtain highly purified natural bioactive compound extracts with potential for the treatment and prevention of various diseases. This research compares the percentage yield of Centella asiatica obtained through freeze drying that was aqueous-extracted earlier by conventional extraction method (decoction and infusion) and an advanced non-conventional extraction method; ultrasound-assisted extraction (UAE).The physical stability of the powder obtained was then tested by hygroscopicity test. The studies were conducted using gravimetric sorption analysis method with slight modification. Each of the powder samples was subjected to the pretreatment at 45 °C, 10% RH followed by equilibrating at 25 °C, 80% RH and individually categorized as per European Pharmacopeia. UAE generated the highest powder yield (11.65%) followed by infusion (10.48%) and decoction (10.03%). After 24 hours of hygroscopicity analysis, all three samples were found to be very hygroscopic since their respective percentage of water sorption was more than 15%. The highest percentage of water sorption was by decoction (71.31%), followed by infusion (71.28%) and lastly UAE (68.71%).