Chao Miao Sheng <br/><br/>
Evaluation of the effects of kyllinga nemoralis cream in rat model of skin-induced allergy / 
Chao Miao Sheng 
 - xii, 69 pages :  illustrations ; 
<br/><br/> Faculty of Industrial Sciences and Technology 
<br/><br/>Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 
<br/><br/>Include bibliographical reference 
<br/><br/> Skin allergies, including atopic dermatitis (AD), are chronic inflammatory conditions that  significantly affect quality of life and pose treatment challenges. This study investigates the therapeutic potential of Kyllinga nemoralis extract, known for its anti-inflammatory  properties, in a rat model of skin-induced allergy. AD-like lesions were induced using  2,4-dinitrochlorobenzene (DNCB), followed by treatment with K. nemoralis cream at 5%  and 10% concentrations. Key metrics, including skin scaling scores, body weight, food  intake, and organ weights (liver and kidney), were evaluated. The 5 % cream significantly  reduced skin scaling scores from 2.80 ± 0.37 to 1.00 ± 0.00 after 7 days, outperforming  the 10% formulation. Liver weights remained unaffected, while untreated lesions showed  significantly different in kidney weight, suggesting potential adverse effects of untreated  AD. The results, comparable to 1% hydrocortisone cream, indicate K. nemoralis as a  promising natural treatment for inflammatory skin conditions. Further studies, including  human trials and pharmacokinetic analyses, are recommended to confirm its clinical  applicability 
<br/><br/><label>ISBN: </label>THE0010289 (Local) 
<br/><br/><label>Subjects--Corporate Names: </label><br/>Faculty of Industrial Sciences and Technology--Dissertations
<br/><br/><label>Subjects--Topical Terms: </label><br/>Universities and colleges--Dissertations<br/>Final Year Report--Dissertations