02408ntm a2200337 i 4500 MY-KuUP 20260120155014.0 t||||fs|||| 000 0 ta 260120t20252025my a|||fs|||| 000 0 eng d THE0010289 (Local) Hardback UMPSA eng UMPSA rda FIST .C43 2025 r Bc. Chao Miao Sheng author. Evaluation of the effects of kyllinga nemoralis cream in rat model of skin-induced allergy / Chao Miao Sheng Kuantan, Pahang : UMPSA, 2025 © 2025 xii, 69 pages : illustrations ; rdacontent text rdamedia unmediated rdacarrier volume rda text file PDF Faculty of Industrial Sciences and Technology Final Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Include bibliographical reference Skin allergies, including atopic dermatitis (AD), are chronic inflammatory conditions that significantly affect quality of life and pose treatment challenges. This study investigates the therapeutic potential of Kyllinga nemoralis extract, known for its anti-inflammatory properties, in a rat model of skin-induced allergy. AD-like lesions were induced using 2,4-dinitrochlorobenzene (DNCB), followed by treatment with K. nemoralis cream at 5% and 10% concentrations. Key metrics, including skin scaling scores, body weight, food intake, and organ weights (liver and kidney), were evaluated. The 5 % cream significantly reduced skin scaling scores from 2.80 ± 0.37 to 1.00 ± 0.00 after 7 days, outperforming the 10% formulation. Liver weights remained unaffected, while untreated lesions showed significantly different in kidney weight, suggesting potential adverse effects of untreated AD. The results, comparable to 1% hydrocortisone cream, indicate K. nemoralis as a promising natural treatment for inflammatory skin conditions. Further studies, including human trials and pharmacokinetic analyses, are recommended to confirm its clinical applicability Faculty of Industrial Sciences and Technology Dissertations Universities and colleges Dissertations Final Year Report Dissertations lcc PSM 0 0 lcc 0 0 10000 10000 2026-01-20 0 FIST .C43 2025 r Bc. T000003668 2026-01-20 15:52:51 2026-01-20 RESTRICT 103896 103902