02319nam a2200313 i 4500003000800000005001700008006001900025007000300044008004100047020003300088040002700121100003000148245012500178264003500303264001200338300003700350336002100387337002500408338002300433347002400456500005000480502013600530504003800666520111000704610006501814650004501879650003701924856004401961MY-KuUP20260127181933.0t||||fs|||| 000 0 ta260127t20252025my a|||fs|||| 000 0 eng d  aTHE0010324 (Local)qHardback  aUMPSAbengcUMPSAerda1 aP’ng Zhe Hung,eauthor.10aEvaluation of anticancer activities  of chistia vespertilionis (red  butterfly wing) on breast cancer /cP’ng Zhe Hung 1aKuantan, Pahang :bUMPSAc2025 4c© 2025  axv, 110 pages :billustrations ;  2rdacontentatext  2rdamediaaunmediated  2rdacarrieravolume  2rdaatext filebPDF  aFaculty of Industrial Sciences and Technology  aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025  aInclude bibliographical reference3 aBreast cancer is a prominent cause of death in women, highlighting the need for new  therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally  been used for its anti-inflammatory and antioxidant effects, may contain bioactive  chemicals that can help treat cancer. The anticancer efficacy of C. vespertilionis leaf  extracts on MCF-7 breast cancer cells were investigated in vitro using Dichloromethane  (DCM) and butanol as solvents. GC-MS study discovered bioactive substances with  anticancer and antioxidant effects, including Phytol, 6-tert-Butyl-2,4-dimethylphenol,  and n-Hexadecanoic acid. The DCM extract had a higher flavonoid content (0.5435 mg  QE/mL), but the butanol extract had a higher phenolic (0.4 mg GAE/mL) and tannin  content (0.09071 mg TAE/mL). Cytotoxicity studies revealed dose-dependent effects,  with IC50 values of 279.64 µg/mL (DCM) and 269.77 µg/mL (butanol). Apoptotic  morphological changes were seen in treated cells. These findings indicate that C.  vespertilionis leaf extracts are a potential source of natural anticancer chemicals.20aFaculty of Industrial Sciences and TechnologyxDissertations 0aUniversities and collegesxDissertations 0aFinal Year ReportxDissertations  uhttp://umpir.ump.edu.my/id/eprint/45705