03036ntm a2200349 i 4500 MY-KuUP 20260714144436.0 t|||||r|||| 000 0 ta 260714t20252025my a|||fr|||| 000 0 eng d THE0010725 (Local) Hardback UMPSA eng UMPSA rda FTKKP .A558 2025 r Bc. Anith Afiqah Nur ‘izzatul Binti Mohamad Saadun, , , author. Fabrication and characterisation of drug-loaded pla-starch-ncc nanofibers via electrospinning for biomedical applications / Anith Afiqah Nur ‘izzatul Binti Mohamad Saadun Kuantan, Pahang : UMPSA, 2025 © 2025 xi, 32 pages : illustrations ; rdacontent text rdamedia unmediated rdacarrier volume rda text file PDF Faculty of Chemical and Process Engineering Technology Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Include bibliographical reference Transdermal drug delivery system (TDDS) has been increasingly focused on achieving greater precision and accuracy at the target site compared to traditional methods. Biopolymer nanofibers are promising for drug delivery systems (DDS) due to their biodegradability, high surface area, and biocompatibility. This study focuses on the fabrication and characterization of nanofibers composed of polylactic acid (PLA), starch, and nanocrystalline cellulose (NCC) with varying concentrations (1 wt%, 3 wt%, and 5 wt%) for biomedical applications. PLA is widely utilised due to its biodegradability and biocompatibility, but its inherent brittleness and hydrophobic nature limit its mechanical performance and water adsorption capacity. To address these limitations, starch was incorporated to enhance hydrophilicity, while NCC was added to reinforce mechanical strength and stability. The nanofibers were fabricated using the needleless electrospinning technique and the morphological, chemical, and mechanical properties of the nanofibers were analysed using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), swelling behaviour, and weight loss analysis. Among the tested formulations, nanofibers with 3 wt% NCC exhibited the larger fiber diameter, swelling resistance, and structural integrity, mitigating PLA’s hydrophobic limitations while maintaining optimal performance. These findings highlight the potential of PLA-starch-NCC nanofibers, particularly at 3 wt% NCC, in developing sustainable and high-performance biomaterials for advanced drug delivery systems. Faculty of Chemical and Process Engineering Technology Dissertations Universities and colleges Dissertations Theses Dissertations https://umpir.ump.edu.my/id/eprint/45608 lcc PSM 0 0 lcc 0 0 10000 10000 2026-07-14 0 FTKKP .A558 2025 r Bc. T000004318 2026-07-14 14:46:09 2026-07-14 PSM 105211 105217