02916ntm a2200337 i 4500 MY-KuUP 20260714172102.0 t|||||r|||| 000 0 ta 260714t20252025my a|||fr|||| 000 0 eng d THE0010730 (Local) Hardback UMPSA eng UMPSA rda FTKKP .K39 2025 r Bc. Kawsalya Pillay A/P Subramaniam, , , author. Optimizing risk management strategies for pharmaceutical water systems through enhanced intergration of machine learning and quantitative risk assessment / Kawsalya Pillay A/P Subramaniam Kuantan, Pahang : UMPSA, 2025 © 2025 xi, 47 pages : illustrations ; rdacontent text rdamedia unmediated rdacarrier volume rda text file PDF Faculty of Chemical and Process Engineering Technology Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Include bibliographical reference Pharmaceutical water systems play a crucial role in ensuring the quality and safety of pharmaceutical products. However, contamination risks and system failures remain significant challenges. This study aims to optimize risk management strategies in pharmaceutical water systems through the enhanced integration of machine learning and quantitative risk assessment (QRA). By adopting this approach, a mathematical model was developed to assess membrane fouling risks in reverse osmosis (RO) systems. The Friday 13th (Fr 13) risk assessment framework was utilized to conduct an in-depth evaluation of potential failures in the RO system. Simulations were performed using @RISK software to identify critical parameters influencing system performance. The obtained data was then validated using Scilab, where machine learning techniques were employed to improve the accuracy of risk predictions. Findings from the study indicate that integrating machine learning with QRA enables more proactive risk monitoring and effective failure management. The developed model allows for more precise assessment of membrane fouling failure probabilities and proposes preventive measures to mitigate risks. This research demonstrates that data-driven analytical approaches enhance the resilience of pharmaceutical water systems against contamination risks and failures. The implications of this study contribute to the improvement of risk management efficiency in the pharmaceutical industry, ensuring compliance with global safety and quality standards. Faculty of Chemical and Process Engineering Technology Dissertations Universities and colleges Dissertations Theses Dissertations lcc PSM 0 0 lcc 0 0 10000 10000 2026-07-14 0 FTKKP .K39 2025 r Bc. T000004323 2026-07-14 17:21:16 2026-07-14 RESTRICT 105216 105222