02827ntm a2200313 i 4500003000800000005001700008006001800025007000300043008004100046020003300087040002700120100005900147245012600206264003600332264001200368300003200380336002100412337002500433338002300458347002400481500005900505502015800564504003800722520156300760610007402323650004502397650002602442856004502468MY-KuUP20260724121033.0t|||||r|||| 000 0ta260724t20252025my a|||fr|||| 000 0 eng d  aTHE0010754 (Local)qHardback  aUMPSAbengcUMPSAerda0 aNurul Hidayah Binti Mohd Zaini,		 						 	,	,eauthor.10aExploring stirrer variations in enhancing carbamazepine saccharin cocrystals properties /cNurul Hidayah Binti Mohd Zaini 1aKuantan, Pahang :bUMPSA,c2025 4c© 2025  a34 pages :billustrations ;  2rdacontentatext  2rdamediaaunmediated  2rdacarrieravolume  2rdaatext filebPDF  aFaculty of Chemical and Process Engineering Technology  aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025  aInclude bibliographical reference3 aCocrystallization improves drug solubility by connecting hydrogen bonds between the active pharmaceutical ingredients and the coformer. Carbamazepine (CBZ) with solubility problems have been studied with saccharin (SAC) to form cocrystal using cooling crystallization method. Mixing is the main process in cooling crystallization to achieve the desired cocrystal, however the research of the stirrer properties is limited. In this study, different types of stirrer which are turbine, paddle and straight stirrers were used to investigate the impact on the cocrystals. The 1:1 ratio of CBZ:SAC was mixed with ethanol in the crystallizer and cooling crystallization was performed for four cycles. After the fourth cycle, the cocrystals were collected and dried for 24 hours. The characterizations testing were conducted using X-ray Diffraction (XRD), Fourier-transform Infrared Spectroscopy (FTIR) and imaging inverted microscopy. Based on crystallization temperature obtained, the straight stirrer formed the cocrystal fastest while the turbine stirrer formed the cocrystal slowest. The FTIR and XRD analysis revealed that all types of stirrer used successfully formed the carbamazepine saccharin cocrystals, while morphology analysis shows that all the cocrystals behave plate-like shape with different sizes. It was concluded that different types of the stirrer used significantly influenced the crystallization temperature and the size of the cocrystal produced highlighting the importance of stirrer selection to produce cocrystal with desired properties.20aFaculty of Chemical and Process Engineering TechnologyxDissertations 0aUniversities and collegesxDissertations 0aThesesxDissertations  uhttps://umpir.ump.edu.my/id/eprint/47666