02802ntm a2200349 i 4500 MY-KuUP 20260724154558.0 t|||||r|||| 000 0 ta 260724t20252025my a|||fr|||| 000 0 eng d THE0010757 (Local) Hardback UMPSA eng UMPSA rda FTKKP .R33 2025 r Bc. Rabiatul Adawiyah Binti Mohd Adnan, , , author. Formulation of quercetin tablets: enhancing solubility with polysorbate 20 / Rabiatul Adawiyah Binti Mohd Adnan Kuantan, Pahang : UMPSA, 2025 © 2025 xi, 57 pages : illustrations ; rdacontent text rdamedia unmediated rdacarrier volume rda text file PDF Faculty of Chemical and Process Engineering Technology Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Include bibliographical reference Quercetin is a bioactive flavonoid present in different types of plant products, which is famous for antioxidative, anti-inflammatory, and therapeutic actions. However, due to its insolubility in water and very poor bioavailability, its effectiveness as an oral health supplement remains very low. The purpose of this study is to formulate and characterize a quercetin tablet formulation employing polysorbate 20 as a solubility-enhancing excipient. The objectives include determining the solubility, dissolution rate, and physical properties of quercetin tablets following the impact of using varying concentrations of polysorbate 20 at concentrations of 2%, 2.75%, 3.5%, 4.25%, and 5%. The technique includes wet granulation to obtain granules and tablet compression through a single-punch tablet press. Tablet friability, hardness, disintegration, and dissolution tests are performed to check the quality and efficacy of the tablets which are in conformities to USP standards. The focus of this research is to overcome the solubility issues associated with quercetin by formulating a higher-yielding method that improves its pharmacological value. Finally, the best composition of polysorbate 20 for formulation of quercetin tablets was 14% of polysorbate 20. In conclusion, this study provides knowledge in the enhancement of oral drug delivery systems of poorly soluble compounds for better therapeutic outcomes and patient compliance. Faculty of Chemical and Process Engineering Technology Dissertations Universities and colleges Dissertations Theses Dissertations https://umpir.ump.edu.my/id/eprint/47715 lcc PSM 0 0 lcc 0 0 10000 10000 2026-07-24 0 FTKKP .R33 2025 r Bc. T000004351 2026-07-24 15:46:15 2026-07-24 PSM 105299 105305