02398nam a2200253 a 4500 vtls000045464 KUKTEM 20251114204425.0 100429t2009 my a f m 000 0 eng|d THE0003851(Local) 201905161541 shah 201107132316 VLOAD 201004291551 ida UMP TP156.A35 R34 2009 rs Bc. Abdul Rahim Mohd Yusoff Antibiotic purification by using IMA adsorbents / Abdul Rahim Bin Mohd Yusoff Antibiotic purification by using IMA adsorbents [electronic resource] Kuantan, Pahang : UMP, 2009 xix, 70 p. : ill. (some col.) ; 30 cm. + 1 computer file Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2009 Bibliography : p. 65-67 The intensity to achieve highly efficient and economical separation process can be seen in developing of various methods in the recent year. While in purification of antibiotic there are many methods use such as using High performance liquid chromatography (HPLC) and Counter-current chromatography (CCC). The purpose of this research is to develop immobilized metal ion affinity zeolite by using solid state ion exchange method to investigate the effect of pH, types of adsorbent using different metal into rifampicin adsorption capacity. Adsorption of rifampicin using zeolite has a greatly potential due to ability to scale up easily, and highly selective. It was found that the highest adsorption capacity for rifampicin occur at pH 8 with Zr-HBeta as adsorbent. H-beta zeolite give highest adsorption capacity because it has higher diameter size, surface area and pore volume compare to Y zeolite. Increasing the surface area and pore volume will give better chances of rifampicin to adsorb into adsorbent. Meanwhile, pH 8 gives the highest adsorption capacity because it is closer with the pKa2 value of rifampicin which is 7.9. While zirconium is the only transition metal containing both acidic and basic surface sites. So this will make it gives better adsorption capacity of rifampicin compare with ferum and nickel. The adsorption isotherm data of rifampicin was well correlated by the Langmuir model. Adsorption 0 0 0 1 10000 10000 2019-09-04 0 TP156.A35 R34 2009 rs Bc. 0000042819 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 3997 | TP156.A35 R34 2009 rs Bc. 0000042820 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 1785 1791 VTLSSORT0080*0200*0400*0900*1000*2450*2460*2600*3000*5020*5040*5200*6500*9992