02842nam a2200217 a 4500001001400000003000700014005001700021008004100038020002200079040000800101100002800109245012500137260003400262300005800296502009000354504002800444520206700472650002002539650003502559650003002594vtls000067095KUKTEM20251114204522.0121128t2012    my a   f m    000 0 eng d  aTHE0003887(Local)  aUMP0 aNur `Afifah Mohd Mansor10aSolvent and temperature effect in the polymorphism study of 2,6-dihydroxybenzoic acid crystal /cNur `Afifah Mohd Mansor  aKuantan, Pahang :bUMP,c2012  axiii, 33 p. :bill. (some col.) ;c30 cm. +e1 CD-ROM  aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012  aBibliography : p. 30-313 aThis researchisabout the solvent and temperature effect in thepolymorphism study of 2,6-Dihydroxybenzoic Acid (2,6DHB)Crystal. Polymorphism is the ability of substance tocrystallize into different crystal structures. Polymorphism is important, as difference in physical properties of polymorphscan impact on issues such as solubility, bioavailability, formulation,patent protection, regulatory compliance and downstream particle handling such as filtration, drying, milling and compaction. The physical properties of polymorphs can be affected by variation of solvent and temperature. Currently, the solvent selection for crystallization is often trial and error procedure(Gu et al., 2004)and polymorphs of 2,6DHB from some solvent is still unknown. This study isaimed to provide guideline for rational choices of solvent with different properties for polymorph screening andas extension to Adam (2011)research. The selection of solvent in this study were based on the polarity of2,6-DHB soluteand solventsmolecule.SolventchosenwereBenzene Formic Acid and Diethylamine. Meanwhile, the temperature that is going to be used are 20, 35and 50oC.The methodology for this study is gravimetric methods for the crystallization and for analysis methods,Vant Hoff equation,XRD, DSC, TGA and optical microscope are going to be used.But due to time limitations only optical microscope analysismethod is used. Differenttype of solvent at specific temperatures have a significant effect in polymorphism of 2,6-DHB crystal and its physical properties.Based on the study, the rank of 2,6-DHB solubility in different solvents are Diethylamine>Formic Acid>Ideal>Benzene. Lowsolutesolvent interactionsand poor solubility was observed in Benzene. The polymorphic characterization analysis has concluded that a Form 1 (plate-like) crystal was observed in Formic Acid and Diethylamine and the crystals are transforming to Form 2(needle-like) based on observation. Form2(needle-like) was observed in Benzene due to prolonged time to achieve supersaturation and limitations of analysis. 0aCrystallization 0aPolymorphism (Crystallography) 0aChemistry, Pharmaceutical