02088nam a2200265 a 4500 vtls000066809 KUKTEM 20251114204530.0 121122t2012 my a f m 000 0 eng d THE0004453(Local) 201905161548 rohana 201211221531 ida UMP TP248.25.S64 M67 2012 rs Bc. Morina Mohd Selih Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation / a Morina Mohd Selih Kuantan, Pahang : UMP, 2012 x, 66 p. : ill. ; 30 cm. + 1 CD-ROM Project paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2012 Bibliography : p. 49-54 Monascus sp. is a non-pathogenic fungus that can produce statin called simvastatin that can lower blood cholesterol in human body. The objective of this research is to investigate the optimization condition of the simvastatin production in solid-state fermentation by Monascus purpureus FTC 5356. The local products that used as substrates were banana, guava, pumpkin, coconut meat, corn, papaya and white rice. The fermentation was conducted using the optimum condition of 50% initial moisture content, pH6 at 30°C for 12 days in order to obtain the best substrate. Among these local products, corn can produce the simvastatin while other five fruits do not produce simvastatin. Further experimental carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM) by setting two parameters which are moisture content and nitrogen source by setting the lower and higher range for each of the parameters. From the analysis from RSM, there are 14 runs conducted to achieve the optimum condition to get the maximum production of simvasatin. Solid-state fermentation Enzymes Industrial applications Statins (Cardiovascular agents) 0 0 0 1 10000 10000 2019-09-04 0 TP248.25.S64 M67 2012 rs Bc. 0000068043 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 6360 | TP248.25.S64 M67 2012 rs Bc. 0000068044 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 3654 3660 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*6502*9992