02098nam a2200277 a 4500 vtls000023939 KUKTEM 20251117144455.0 080201s2006 gw a f bi 001 0 eng d 3527314865 (alk. paper) 9783527314867 (alk. paper) 201201311638 ida 201107132237 VLOAD 200908141406 VLOAD 200908141337 VLOAD 200802011131 norsaini UMP RC268.5 .K52 2006 Kiaris, Hippokratis Understanding carcinogenesis : an introduction to the molecular basis of cancer / Hippokratis Kiaris Weinheim : Wiley-VCH, c2006 x, 177 p. : ill. ; 24 cm. Includes bibliographical references and index Some introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue Cell Transformation, Neoplastic genetics Carcinogenesis Molecular aspects. Cancer Genetic aspects. Mutation (Biology) 0 0 0 0 10000 10000 2019-09-04 95.00 0 RC268.5 .K52 2006 0000031581 2019-09-04 00:00:00 1 95.00 2019-09-04 OPEN VIRTUA40 37042 37048 VTLSSORT0080*0200*0201*0400*0900*1000*2450*2600*3000*5040*5050*6500*6501*6502*6503*9991