an introduction to the molecular basis of cancer Kiaris, Hippokratis creator text bibliography gw Weinheim Wiley-VCH c2006 2006 monographic eng

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x, 177 p. : ill. ; 24 cm. Some introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue specialized Hippokratis Kiaris Includes bibliographical references and index Cell Transformation, Neoplastic genetics Carcinogenesis Molecular aspects Cancer Genetic aspects Mutation (Biology) 3527314865 (alk. paper) 9783527314867 (alk. paper) UMP 080201 20251117144455.0 vtls000023939