03695nam a2200361 a 4500001001400000003000700014005001700021008004100038010001600079020004200095020004200137020004200179020004500221020001800266020001800284040000800302245009800310260004100408300003900449504005100488505113500539505127801674650002602952650001502978650002602993650002103019650002703040700001703067700002603084700002503110856010603135856009203241vtls000025014KUKTEM20251117144516.0080304t2005    gw a   f bi   001 0 eng d  a2006-436556  a3527308377 (v. 1 : hbk. : alk. paper)  a3527311300 (v. 2 : hbk. : alk. paper)  a3527314350 (v. 3 : hbk. : alk. paper)  a9783527314362 (v. 4 : hbk. : alk. paper)  a9783527308378  a9783527314355  aUMP00aProtein degradation /c[edited by] R. John Mayer, Aaron Ciechanover, Martin Rechsteiner, eds.  aWeinheim :bWiley-VCH,cc2005-c2008.  a4 v. :bill. (some col.) ;c25 cm.  aIncludes bibliographical references and index.1 av. 1. Ubiquitin and the chemistry of life. 1. Brief history of protein degradation and the ubiquitin system / Avram Hershko -- 2. N-terminal ubiquitination: no longer such a rare modification / Aaron Ciechanover -- 3. Evolutionary origin of the activation step during ubiquitin-dependent protein degradation / Hermann Schindelin -- 4. RING fingers and relatives: determinators of protein fate / Kevin L. Lorick ... [et al.] -- 5. Ubiquitin-conjugating enzymes / Michael J. Eddins and Cecile M. Pickart -- 6. The SCF ubiquitin E3 ligase / Leigh Ann Higa and Hui Zhang -- 7. The structural biology of ubiquitin-protein ligases / Ning Zheng and Nikola P. Pavletich -- 8. The deubiquitinating enzymes / Nathaniel S. Russell and Keith D. Wilkinson -- 9. The 26S proteasome / Martin Rechsteiner -- 10. Molecular machines for protein degradation / Matthias Bochtler ... [et al.] -- 11. Proteasome regulator, PA700 (19S regulatory particle) / George N. DeMartino and Cezary Wojcik -- 12. Bioinformatics of ubiquitin domains and their binding partners / Kay Hofmann -- 13. The COP9 signalosome: its possible role in the ubiquitin system --0 av. 2. The ubiquitin-proteasome system. 1. Molecular chaperones and the ubiquitin-proteasome system / Cam Patterson and Jörg Höhfeld -- 2. Molecular dissection of autophagy in the yeast Saccharomyces cerevisiae / Yoshinori Ohsumi -- 3. Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes / Huib Ovaa ... [et al.] -- 4. MEKK1: dual function as a protein kinase and a ubiquitin protein ligase / Zhimin Lu and Tony Hunter -- 5. Proteasome activators / Andreas Förster and Christopher P. Hill -- 6. The proteasome portal and regulation of proteolysis / Monika Bajorek and Michael H. Glickman -- 7. Ubiquity and diversity of the proteosome system / Keiji Tanaka, Hideki Yashiroda, and Shigeo Murata -- 8. Proteasome-interacting proteins / Jean E. O'Donoghue and Colin Gordon -- 9. Structural studies of large, self-compartmentalizing proteases / Beate Rockel, Jürgen Bosch, and Wolfgang Baumeister -- 10. What the archaeal PAN - proteasome complex and bacterial ATP-dependent proteases can teach us about the 26S proteasome / Nadia Benaroudj, David Smith, and Alfred L. Goldberg -- 11. Biochemical functions of ubiquitin and ubiquitin-like protein conjugation / Mark Hochstrasser -- v. 4. The Ubiquitin-Proteasome System and disease. 0aProteinsxMetabolism. 0aUbiquitin.12aProteinsxmetabolism.22aCell Physiology.22aUbiquitinxphysiology.1 aMayer, R. J.1 aCiechanover, Aaron J.1 aRechsteiner, Martin.423Contributor biographical informationuhttp://www.loc.gov/catdir/enhancements/fy0644/2006436556-b.html423Table of contents onlyuhttp://www.loc.gov/catdir/enhancements/fy0644/2006436556-t.html