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  <titleInfo>
    <title>Protein degradation</title>
  </titleInfo>
  <name type="personal">
    <namePart>Mayer, R. J.</namePart>
  </name>
  <name type="personal">
    <namePart>Ciechanover, Aaron J.</namePart>
  </name>
  <name type="personal">
    <namePart>Rechsteiner, Martin.</namePart>
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    <place>
      <placeTerm type="text">Weinheim</placeTerm>
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    <publisher>Wiley-VCH</publisher>
    <dateIssued>c2005-c2008</dateIssued>
    <dateIssued encoding="marc">2005</dateIssued>
    <issuance>monographic</issuance>
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  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
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    <extent>4 v. : ill. (some col.) ; 25 cm.</extent>
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  <tableOfContents>v. 1. Ubiquitin and the chemistry of life. 1. Brief history of protein degradation and the ubiquitin system / Avram Hershko -- 2. N-terminal ubiquitination: no longer such a rare modification / Aaron Ciechanover -- 3. Evolutionary origin of the activation step during ubiquitin-dependent protein degradation / Hermann Schindelin -- 4. RING fingers and relatives: determinators of protein fate / Kevin L. Lorick ... [et al.] -- 5. Ubiquitin-conjugating enzymes / Michael J. Eddins and Cecile M. Pickart -- 6. The SCF ubiquitin E3 ligase / Leigh Ann Higa and Hui Zhang -- 7. The structural biology of ubiquitin-protein ligases / Ning Zheng and Nikola P. Pavletich -- 8. The deubiquitinating enzymes / Nathaniel S. Russell and Keith D. Wilkinson -- 9. The 26S proteasome / Martin Rechsteiner -- 10. Molecular machines for protein degradation / Matthias Bochtler ... [et al.] -- 11. Proteasome regulator, PA700 (19S regulatory particle) / George N. DeMartino and Cezary Wojcik -- 12. Bioinformatics of ubiquitin domains and their binding partners / Kay Hofmann -- 13. The COP9 signalosome: its possible role in the ubiquitin system --</tableOfContents>
  <tableOfContents>v. 2. The ubiquitin-proteasome system. 1. Molecular chaperones and the ubiquitin-proteasome system / Cam Patterson and Jörg Höhfeld -- 2. Molecular dissection of autophagy in the yeast Saccharomyces cerevisiae / Yoshinori Ohsumi -- 3. Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes / Huib Ovaa ... [et al.] -- 4. MEKK1: dual function as a protein kinase and a ubiquitin protein ligase / Zhimin Lu and Tony Hunter -- 5. Proteasome activators / Andreas Förster and Christopher P. Hill -- 6. The proteasome portal and regulation of proteolysis / Monika Bajorek and Michael H. Glickman -- 7. Ubiquity and diversity of the proteosome system / Keiji Tanaka, Hideki Yashiroda, and Shigeo Murata -- 8. Proteasome-interacting proteins / Jean E. O'Donoghue and Colin Gordon -- 9. Structural studies of large, self-compartmentalizing proteases / Beate Rockel, Jürgen Bosch, and Wolfgang Baumeister -- 10. What the archaeal PAN - proteasome complex and bacterial ATP-dependent proteases can teach us about the 26S proteasome / Nadia Benaroudj, David Smith, and Alfred L. Goldberg -- 11. Biochemical functions of ubiquitin and ubiquitin-like protein conjugation / Mark Hochstrasser -- v. 4. The Ubiquitin-Proteasome System and disease.</tableOfContents>
  <targetAudience authority="marctarget">specialized</targetAudience>
  <note type="statement of responsibility">[edited by] R. John Mayer, Aaron Ciechanover, Martin Rechsteiner, eds.</note>
  <note>Includes bibliographical references and index.</note>
  <subject authority="lcsh">
    <topic>Proteins</topic>
    <topic>Metabolism</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Ubiquitin</topic>
  </subject>
  <subject authority="mesh">
    <topic>Proteins</topic>
    <topic>metabolism</topic>
  </subject>
  <subject authority="mesh">
    <topic>Cell Physiology</topic>
  </subject>
  <subject authority="mesh">
    <topic>Ubiquitin</topic>
    <topic>physiology</topic>
  </subject>
  <identifier type="isbn">3527308377 (v. 1 : hbk. : alk. paper)</identifier>
  <identifier type="isbn">3527311300 (v. 2 : hbk. : alk. paper)</identifier>
  <identifier type="isbn">3527314350 (v. 3 : hbk. : alk. paper)</identifier>
  <identifier type="isbn">9783527314362 (v. 4 : hbk. : alk. paper)</identifier>
  <identifier type="isbn">9783527308378</identifier>
  <identifier type="isbn">9783527314355</identifier>
  <identifier type="lccn">2006-436556</identifier>
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