02203nam a2200277 a 4500 vtls000075737 KUKTEM 20251114204542.0 131025t2013 my da f abm 000 0 eng d THE0003886(Local) 201905161511 shah 201310251530 nabilah UMP TP156.C7 A33 2013 rs Bc. Nur Aida Zakiriah Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal / Nur Aida Zakiriah Kuantan, Pahang : UMP, 2013 xv, 70 p. : ill. ; 30 cm. + 1 CD-ROM Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2013 Bibliography : p. 51-52 A research was conducted on the solid phase transformation and stability of carbamazepine-saccharin co-crystal. Pharmaceutical co-crystal is one of the potential methods for improving the bioavailibity of drugs with low aqueous solubility. Thus, the purpose of this research is to determine the stable region of carbamazepine-saccharin (CBZ-SAC) co-crystal formation by using solution based method. In this method, three technique are used which are cooling crystallization, solvent evaporation and slurry, to prepare the chemical and use ethanol as a solvent. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC cocrystal formation. Physical characterizations of the co-crystal are being characterized by differential scanning calorimetry and research microscope. Overall as the concentration of saccharin increase the melting point increase and will lead to poor solubility but mostly the melting point of co-crystal resulting in lower melting point. From this research can be concluded that CBZ-SAC co-crystal can form two forms which are plate-like and needle like. Varying the mol of carbamazepine and used different solvents could be used for further studies to see the difference trending. Crystallization Drugs Solubility Carbamazepine Saccharin 0 0 0 1 10000 10000 2019-09-04 0 TP156.C7 A33 2013 rs Bc. 0000074627 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 7013 | TP156.C7 A33 2013 rs Bc. 0000074628 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 3985 3991 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*6502*6503*9992