02576nam a2200253 a 4500 vtls000076090 KUKTEM 20251114204546.0 131113t2013 my da f m 000 0 eng d THE0002307(Local) 201905271036 shamsul 201311131434 nabilah UMP RC271.C5 S93 2013 rs Bc. Muhammad Syafiq Abd Rahman Nanobeads formation for anticancer drug release controlled by electrospinning / Muhammad Syafiq Abd Rahman Kuantan, Pahang : UMP, 2013 xiii, 47 p. : ill. ; 30 cm. + 1 CD-ROM Project paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang – 2013 Bibliography : p. 40-42 Anticancer drug nowadays have become one of the most important industry in the world. In order to improve drug delivery, the used of nanoparticles is the main purpose for this research study. The objectives for this study are to investigate the morphology of nanoparticles produced based on different molecular weight of and concentration of Polyethylene Oxide (PEO). In this research, a very high molecular weight (MR) PEO is used as the core polymer. Two types of PEO used are with 400 000 MW and 900 000 MW. There are two types of solvents used that are distilled water and ethanol. Whey protein is used because it containing Cysteine, one of the sulphur-containing amino acid and has same properties as anticancer drug. Henceforth, whey protein is used because it is easily to purchase and cheaper. PEO acts as shell that encapsulated the drug. There are two main processes for the nanoparticles preparation that are solution preparation and electrospinning. Four types of solution are prepared; PEO with water, PEO with Ethanol, PEO with protein, and PEO with protein and ethanol. All samples are prepared till 10 mL and 20 mL and then go through the electrospinning about 5 hours. After electrospinnig the samples will be analyzed under Field Emission Scanning Electron Microscopy (FESEM) to observe the morphology of nanoparticles and Energy Dispersive X- Ray (EDX) for sulphur determination. The resulted obtained showed the lower the viscosity, the more the formation of nanobeads. Lower molecular weight also affects the nanobeads formation as lower molecular weight is more beads than higher molecular weight. Antineoplastic agents Nanoparticles 0 0 0 1 10000 10000 2019-09-04 0 RC271.C5 S93 2013 rs Bc. 0000074747 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 7073 | RC271.C5 S93 2013 rs Bc. 0000074748 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 4118 4124 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*9992