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  <titleInfo>
    <title>Chemistry and molecular aspects of drug design and action</title>
  </titleInfo>
  <name type="personal">
    <namePart>Rekka, E. A.</namePart>
  </name>
  <name type="personal">
    <namePart>Kourounakis, P. N.</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
  <genre authority="marc">bibliography</genre>
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    <place>
      <placeTerm type="text">Boca Raton</placeTerm>
    </place>
    <publisher>CRC Press/Taylor &amp; Francis</publisher>
    <dateIssued>c2008</dateIssued>
    <dateIssued encoding="marc">2008</dateIssued>
    <issuance>monographic</issuance>
  </originInfo>
  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
  </language>
  <physicalDescription>
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    <extent>xxii, 356 p. : ill. ; 25 cm.</extent>
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  <tableOfContents>Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / Joseph Rogers ... [et al.] -- Treatment development strategies for Alzheimer's disease / Ernst Wülfert -- Lipoprotein-associated phospholipase A?b2?s as a new prognostic factor for coronary artery disease / Alexandros D. Tselepis -- New molecular targets for the prevention and treatment of gastrointestinal ulcers and inflammation / Sandor Szabo ... [et al.] -- Stress activates corticotropin releasing : factor signaling pathways : implication in functional bowel disorders / Yvette Taché -- Design, synthesis, and pharmacological evaluation of high-affinity and selectivity sigma-1 and sigma-2 receptor ligands / Jacques H. Poupaert -- Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy -- From the molecular pharmacology to the medicinal chemistry of cannabinoids / Didier M. Lambert -- An appraisal of fomocaines : current situation and outlook / Herbert Oelschläger and Andreas Seeling -- Ligands for the GABA recognition site at the GABAA receptor : structure-activity studies / Bente Frølund ... [et al.] -- Strategies for development of new lead structures for inhibition of acetylcholinesterase / Petra Kapkova ... [et al.] -- Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2) : a new target for the treatment of congestive heart failure and myocardial fibrosis--a review / R.W. Hartmann ... [et al.] --</tableOfContents>
  <tableOfContents>Thiocarboxanilides : a new class of nonnucleoside reverse transcriptase inhibitors (NNRTIs) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini -- Histamine H?b3?s-receptor agonists and antagonists : chemical, pharmacological, and clinical aspects / Holger Stark and Walter Schunack -- Anti-inflammatory actions of flavonoids and structural requirements for new design / Theoharis C. Theoharides -- Molecular mechanisms of H?b2?sO?b2?s-induced DNA damage : the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris -- LNA (locked nucleic acid) and functionalized LNA : towards efficient gene targeting / Jesper Wengel -- The effect of diet on drug metabolism / K.J. Netter -- Cytochromes P450 in the metabolism and bioactivation of chemicals / Costas Ioannides -- In vitro methods to measure drug metabolism and drug interactions in drug discovery and development / O. Pelkonen ... [et al.] -- How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter -- Physicochemical profiling in early drug discovery : new challenges at the age of high-throughput screen and combinatorial chemistry / Bernard Faller -- Drug membrane interaction and its importance for drug efficacy / J.K. Seydel ... [et al.] -- The fight against AIDS : new avenues for inhibiting reverse transcriptase (RT), and old target / Maurizio Botta ... [et al.]</tableOfContents>
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  <note type="statement of responsibility">[edited by] E.A. Rekka, P.N. Kourounakis</note>
  <note>Includes bibliographical references and index</note>
  <subject authority="lcsh">
    <topic>Pharmaceutical chemistry</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Drugs</topic>
    <topic>Design</topic>
  </subject>
  <subject authority="mesh">
    <topic>Chemistry, Pharmaceutical</topic>
  </subject>
  <subject authority="mesh">
    <topic>Drug Design</topic>
  </subject>
  <subject authority="mesh">
    <topic>Pharmacologic Actions</topic>
  </subject>
  <identifier type="isbn">9780849390067 (hbk. : alk. paper)</identifier>
  <identifier type="isbn">0849390060 (hbk. : alk. paper)</identifier>
  <identifier type="uri">http://www.loc.gov/catdir/toc/ecip0712/2007010012.html</identifier>
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    <url displayLabel="Table of contents only">http://www.loc.gov/catdir/toc/ecip0712/2007010012.html</url>
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    <recordCreationDate encoding="marc">090617</recordCreationDate>
    <recordChangeDate encoding="iso8601">20251117145415.0</recordChangeDate>
    <recordIdentifier source="KUKTEM">vtls000038039</recordIdentifier>
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