01861ntm a2200217 a 4500001001400000003000700014005001700021008004100038020002200079040000800101100003200109245009900141260003400240300004400274500005600318502009200374504002800466520111100494650002001605650001801625vtls000084820KUKTEM20251117113230.0150113t2014    my a   f m    000 0 eng d  aTHE0003892(Local)  aUMP0 aEngku Nadia Engku Mat Nasir10aSolid phase transformation of carbamazepine-succinic co-crystal /cEngku Nadia Engku Mat Nasir  aKuantan, Pahang :bUMP,c2014  axv, 37 p. :bill. ;c30 cm. +e1 CD-ROM  aFaculty of Chemical & Natural Resources Engineering  aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014  aBibliography : p. 28-313 aThis paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed 0aCrystallization 0aCarbamazepine